Jack Sadelstein, a successful advertising executive in Los Angeles with a beautiful wife and kids, dreads one event each year: the Thanksgiving visit of his twin sister Jill. Jill's neediness and passive-aggressiveness is maddening to Jack, turning his normally tranquil life upside down.
| Directing | Dennis Dugan | Director |
| Writing | Steve Koren | Screenplay |
| Writing | Adam Sandler | Screenplay |
| Crew | Scott Rogers | Stunt Coordinator |
| Writing | Ben Zook | Story |
| Camera | Dean Cundey | Director of Photography |
| Editing | Tom Costain | Editor |
| Art | Perry Andelin Blake | Production Design |
| Costume & Make-Up | Ellen Lutter | Costume Design |
| Art | Ronald R. Reiss | Set Decoration |
| Directing | Ronit Ravich-Boss | Script Supervisor |
| Visual Effects | Dottie Starling | Visual Effects Supervisor |
| Production | Roger Mussenden | Casting |
| Production | Jeremy Rich | Casting |
| Production | Kevin Grady | Co-Producer |
| Sound | Michael Dilbeck | Music Supervisor |
| Sound | Brooks Arthur | Music Supervisor |
| Sound | Kevin Grady | Music Supervisor |
| Sound | Rupert Gregson-Williams | Original Music Composer |
| Sound | Waddy Wachtel | Original Music Composer |
| Production | Barry Bernardi | Executive Producer |
| Production | Bettina Sofia Viviano | Executive Producer |
| Production | Allen Covert | Executive Producer |
| Production | Steve Koren | Executive Producer |
| Production | Robert Smigel | Executive Producer |
| Production | Tim Herlihy | Executive Producer |
| Production | Todd Garner | Producer |
| Production | Adam Sandler | Producer |
| Production | Jack Giarraputo | Producer |
| Production | Daryl Kass | Associate Producer |
| Production | Daryl Kass | Unit Production Manager |
| Directing | Daniel Silverberg | First Assistant Director |
| Directing | Conte Mark Matal | Second Assistant Director |
| Visual Effects | Dan DeLeeuw | Visual Effects Supervisor |
| Art | Alan Au | Art Direction |
| Art | John Collins | Art Direction |
| Art | Timothy S. Wiles | Property Master |
| Camera | Casey Hotchkiss | Camera Operator |
| Camera | Candide Franklyn | Steadicam Operator |
| Camera | William Coss | First Assistant Camera |
| Camera | Baird Steptoe | First Assistant Camera |
| Camera | R. Scott Goodrich | Second Assistant Camera |
| Camera | Eric S. Guthrie | Second Assistant Camera |
| Camera | Raul Riveros | Digital Imaging Technician |
| Costume & Make-Up | Valerie Zielonka | Costume Supervisor |
| Costume & Make-Up | Elaine Ramires | Key Costumer |
| Costume & Make-Up | Ann Pala | Makeup Department Head |
| Costume & Make-Up | Kathleen Freeman | Key Makeup Artist |
| Costume & Make-Up | Bonita DeHaven | Makeup Artist |
| Costume & Make-Up | Carme Tenuta | Makeup Artist |
| Costume & Make-Up | Julie Hewett | Makeup Artist |
| Costume & Make-Up | Thomas Real | Hair Department Head |
| Costume & Make-Up | Nancy Tong | Key Hair Stylist |
| Costume & Make-Up | Dena Fayne | Hairstylist |
| Costume & Make-Up | Cydney Cornell | Hairstylist |
| Lighting | Michael Orefice | Gaffer |
| Camera | Frank A. Montesanto | Key Grip |
| Sound | Richard Kite | Sound Mixer |
| Sound | Anthony Ortiz | Boom Operator |
| Crew | Alfred Ainsworth | Video Assist Operator |
| Sound | Thomas Giordano | Utility Sound |
| Crew | Larz Anderson | Special Effects Coordinator |
| Crew | Mark Yuricich | Special Effects Technician |
| Production | Rob Frank | Location Manager |
| Production | Robert Paulsen | Assistant Location Manager |
| Art | David Elliott | Construction Coordinator |
| Art | Robert Fechtman | Set Designer |
| Art | Martha Johnston | Set Designer |
| Art | Cindy M. Ichikawa | Art Department Coordinator |
| Art | Bruce Luizzi | Leadman |
| Art | Chuck Askerneese | Assistant Property Master |
| Crew | Tammy Sandler | Unit Publicist |
| Camera | Tracy Bennett | Still Photographer |
| Crew | Juan J. Rodriguez | Transportation Captain |
| Crew | Chad Moore | Transportation Co-Captain |
| Crew | Randy Lovelady | Transportation Co-Captain |
| Crew | Patsy Bouge | Post Production Supervisor |
| Editing | Stephen Shapiro | First Assistant Editor |
| Editing | Sarah Lucky | Assistant Editor |
| Crew | Jamie Keeney | Visual Effects Editor |
| Sound | Tateum Kohut | Sound Re-Recording Mixer |
| Sound | Greg Orloff | Sound Re-Recording Mixer |
| Sound | Elmo Weber | Supervising Sound Editor |
| Sound | Russell Farmarco | Supervising Sound Editor |
| Sound | Matthew P. Hanson | Assistant Sound Editor |
| Sound | Joe Lemola | Sound Effects Editor |
| Sound | Marc Glassman | Sound Effects Editor |
| Sound | Cameron Steenhagen | Dialogue Editor |
| Sound | David Williams | Dialogue Editor |
| Sound | Richard E. Yawn | Dialogue Editor |
| Sound | Amy Kane | Foley Artist |
| Sound | Anita Cannella | Foley Artist |
| Sound | Jeff Gross | Foley Mixer |
| Sound | J.J. George | Music Editor |
| Sound | Stuart Grusin | Music Editor |
| Sound | Alastair King | Orchestrator |
| Crew | Eboni Nichols | Choreographer |
| Crew | Clay Cullen | Stunt Double |
| Crew | Shawnna Thibodeau | Stunt Double |
| Crew | Steve Kelso | Stunt Double |
| Crew | Tom Elliott | Stunts |
| Crew | Jeremy Fry | Stunt Driver |
| Crew | Mickey Giacomazzi | Stunts |
