Deadpool tells the origin story of former Special Forces operative turned mercenary Wade Wilson, who after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.
| Production | Ronna Kress | Casting |
| Crew | Sala Baker | Stunts |
| Production | Lauren Shuler Donner | Producer |
| Production | Stan Lee | Executive Producer |
| Writing | Rhett Reese | Screenplay |
| Production | Rhett Reese | Executive Producer |
| Art | Sean Haworth | Production Design |
| Production | Simon Kinberg | Producer |
| Costume & Make-Up | Angus Strathie | Costume Design |
| Costume & Make-Up | Bill Corso | Makeup Designer |
| Production | Ryan Reynolds | Producer |
| Production | John J. Kelly | Executive Producer |
| Sound | R.J. Kizer | ADR & Dubbing |
| Directing | Tim Miller | Director |
| Sound | Tim Gomillion | Sound Recordist |
| Sound | Warren Hendriks | Sound Designer |
| Sound | Warren Hendriks | Supervising Sound Editor |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Sound | Junkie XL | Original Music Composer |
| Crew | Krista Bell | Stunts |
| Crew | Ric Walkington | Armorer |
| Editing | Julian Clarke | Editor |
| Production | Jonathon Komack Martin | Executive Producer |
| Writing | Paul Wernick | Screenplay |
| Production | Paul Wernick | Executive Producer |
| Writing | Jay Oliva | Storyboard |
| Writing | Rob Liefeld | Characters |
| Art | Greg Berry | Art Direction |
| Camera | Ken Seng | Director of Photography |
| Production | Corinne Clark | Casting |
| Production | Jennifer Page | Casting |
| Crew | Amy Johnston | Stunts |
| Art | Nigel Evans | Art Direction |
| Writing | Fabian Nicieza | Characters |
| Crew | Wayne Dalglish | Stunts |
| Production | Aditya Sood | Executive Producer |
| Costume & Make-Up | Susan O'Hara | Costume Supervisor |
| Sound | Dan O'Connell | Foley |
| Sound | Craig Henighan | Sound Designer |
| Sound | Ai-Ling Lee | Sound Designer |
| Sound | Ted Caplan | Music Editor |
| Costume & Make-Up | Silke Guglielmo | Set Costumer |
| Sound | Susan Dawes | Supervising Dialogue Editor |
| Sound | Will Files | Sound Re-Recording Mixer |
| Lighting | Drew Davidson | Gaffer |
| Camera | Norbert Kaluza | Steadicam Operator |
| Camera | Joseph Lederer | Still Photographer |
| Sound | Jim Brookshire | Supervising Sound Editor |
| Sound | Benjamin Beardwood | Sound Editor |
| Sound | Wayne Lemmer | Supervising Sound Editor |
| Lighting | Burton 'Joe' Kuchera | Gaffer |
| Sound | Laura Graham | ADR Editor |
| Visual Effects | Pimentel A. Raphael | Animation Supervisor |
| Camera | Dean Heselden | Camera Operator |
| Sound | Teri E. Dorman | Dialogue Editor |
| Visual Effects | Shaun Friedberg | Animation Director |
| Camera | Stephen Maier | Camera Operator |
| Art | Nevin Swain | Property Master |
| Visual Effects | Alex Burdett | Special Effects Supervisor |
| Art | Shannon Gottlieb | Set Decoration |
| Crew | Robert Alonzo | Stunt Coordinator |
| Production | Hannah d'Angerio | Casting Associate |
| Sound | John Houlihan | Music Supervisor |
| Camera | Richard Roles | Helicopter Camera |
| Visual Effects | Tamar Shaham | Visual Effects Coordinator |
| Visual Effects | Tim Weber | Visual Effects Coordinator |
| Visual Effects | Brittany Montero | Visual Effects Coordinator |
| Crew | Rochelle Okoye | Stunts |
| Lighting | Keith Woods | Rigging Gaffer |
| Camera | Kieran Humphries | First Assistant Camera |
| Crew | Rob Fournier | Armorer |
| Camera | Doug Lavender | First Assistant Camera |
| Camera | David Dolsen | Still Photographer |
| Art | Teresa Ngan | Art Department Coordinator |
| Art | Marc Aubin | Art Department Assistant |
| Costume & Make-Up | Michael Mew | Assistant Costume Designer |
| Costume & Make-Up | Erin da Roza | Set Costumer |
| Costume & Make-Up | Amy Schilbe | Set Costumer |
| Camera | Sasha Proctor | Camera Operator |
| Camera | Mark Cohen | Camera Operator |
| Lighting | Adam Bunz | Rigging Grip |
| Lighting | Herb DeWaal | Rigging Grip |
| Lighting | Daryl Makortoff | Rigging Grip |
| Camera | Jeff Sayle | First Assistant Camera |
| Camera | James Claire | First Assistant Camera |
| Visual Effects | Jan Philip Cramer | Animation Director |
| Visual Effects | Luke Botteron | VFX Editor |
| Editing | Matthew G. Carson | First Assistant Editor |
| Visual Effects | Teresa Berus | Visual Effects Coordinator |
| Visual Effects | Patrick Thomas O'Rourke | Visual Effects Coordinator |
| Visual Effects | Sammy Shikaze | Visual Effects Coordinator |
| Visual Effects | Dipankar Sarkar | Visual Effects Coordinator |
| Visual Effects | Cole Darby | Visual Effects Coordinator |
| Visual Effects | Sara Bourque | Visual Effects Coordinator |
| Visual Effects | Thibaud Galbois | Visual Effects Coordinator |
| Crew | Atlin Mitchell | Stunts |
| Crew | Natasha Denis | Stunts |
| Crew | David Goyer | Generator Operator |
| Production | Thane Watkins | Associate Producer |
