Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
| Production | Guillermo del Toro | Producer |
| Production | Steven Hoban | Producer |
| Writing | Antoinette Terry Bryant | Screenplay |
| Writing | Vincenzo Natali | Screenplay |
| Production | Jason Knight | Casting |
| Costume & Make-Up | Marie Nardella | Makeup Department Head |
| Costume & Make-Up | Alex Kavanagh | Costume Design |
| Art | Todd Cherniawsky | Production Design |
| Writing | Doug Taylor | Screenplay |
| Directing | Vincenzo Natali | Director |
| Production | John Buchan | Casting |
| Art | Joshu de Cartier | Art Direction |
| Production | Constance Demontoy | Casting |
| Art | Sam Hudecki | Assistant Art Director |
| Sound | David McCallum | Supervising Sound Editor |
| Sound | Roderick Deogrades | Sound Effects Editor |
| Visual Effects | Jean-François Bourrel | Visual Effects Producer |
| Camera | Steve Wilkie | Still Photographer |
| Sound | Shie Rozow | Music Editor |
| Crew | Dana Howes | Transportation Coordinator |
| Sound | Stefan Fraticelli | Foley |
| Crew | Michael Griffith | Visual Effects Editor |
| Crew | Paul Rapovski | Stunt Coordinator |
| Camera | Dino Laurenza | Camera Operator |
| Sound | Laurent Kossayan | Supervising Sound Editor |
| Sound | John Sievert | Foley |
| Sound | Mark Shnuriwsky | Sound Effects Editor |
| Sound | Brad Sherman | Sound Re-Recording Mixer |
| Lighting | Chris Howard | Gaffer |
| Sound | David Rose | Sound Designer |
| Editing | Aidan Stanford | Color Timer |
| Visual Effects | Alain Lalanne | Visual Effects Producer |
| Camera | Angelo Colavecchia | Camera Operator |
| Editing | Christopher M. Meagher | Digital Intermediate |
| Directing | Lisa Burling | Script Supervisor |
| Crew | Daniel White | Special Effects Coordinator |
| Visual Effects | François-Xavier Aubague | Visual Effects Producer |
| Visual Effects | David Sanger | Visual Effects Producer |
| Crew | Chris Howard | Thanks |
| Production | Joseph Boccia | Production Manager |
| Sound | Garrett Kerr | Sound Effects Editor |
| Visual Effects | Pierre Buffin | Visual Effects Supervisor |
| Costume & Make-Up | Leslie Kavanagh | Costume Supervisor |
| Crew | Rossana DeCampo | Scenic Artist |
| Visual Effects | Jacques Bled | Visual Effects Producer |
| Visual Effects | Bob Munroe | Visual Effects Supervisor |
| Crew | Plato Fountidakis | Stunt Coordinator |
| Production | Marty Dejczak | Location Manager |
| Costume & Make-Up | David R. Beecroft | Hairstylist |
| Art | Jason Lunn | Leadman |
| Visual Effects | Arnauld Boulard | Visual Effects Producer |
| Visual Effects | Ian Hunter | Visual Effects Supervisor |
| Art | William Cheng | Set Designer |
| Visual Effects | Fabrice Lagayette | Visual Effects Supervisor |
| Sound | Steve Pederson | Sound Re-Recording Mixer |
| Visual Effects | Dale Gagne | Visual Effects Producer |
| Crew | Sue Len Quon | Visual Effects Editor |
| Visual Effects | Christina Butterfield | VFX Artist |
| Writing | Antoinette Terry Bryant | Story |
| Sound | Jean-Alexandre Villemer | Sound Recordist |
| Sound | Cyrille Aufort | Original Music Composer |
| Editing | Michele Conroy | Editor |
| Writing | Vincenzo Natali | Story |
| Sound | Lou Thomas | Dialogue Editor |
| Camera | Tetsuo Nagata | Director of Photography |
| Sound | Janice Ierulli | Dialogue Editor |
| Art | James R. Murray | Property Master |
| Sound | Jill Purdy | Dialogue Editor |
| Crew | Cynthia Amsden | Unit Publicist |
| Production | Franck Chorot | Producer |
| Camera | David Herrington | Second Unit Director of Photography |
| Lighting | Desiree Lidon | Electrician |
| Camera | Mark Manchester | Key Grip |
| Camera | Amanda Wojtaszek | Camera Loader |
| Directing | Bob Munroe | Second Unit Director |
| Camera | Mark Cyre | First Assistant "A" Camera |
| Crew | Hubert Boorder | Stunt Double |
| Art | Mario Moreira | Assistant Property Master |
| Directing | Sarah Campbell | Second Assistant Director |
| Camera | Jeff DaSilva | Second Assistant Camera |
| Camera | John Colavecchia | First Assistant "B" Camera |
| Crew | Christopher Cordell | Stunt Double |
| Directing | Andrew Shea | First Assistant Director |
| Art | Marc Kuitenbrouwer | Construction Coordinator |
| Costume & Make-Up | Julia Valente | Assistant Makeup Artist |
| Costume & Make-Up | Lydia Pensa | Assistant Hairstylist |
| Crew | Jane Conway | Animal Wrangler |
| Sound | Steve Copley | Foley Recordist |
| Sound | Michel Monier | Dolby Consultant |
| Sound | Brandon Prodger | ADR Recordist |
| Editing | Chris Wallace | Digital Intermediate Colorist |
| Editing | Peter Armstrong | Digital Intermediate Producer |
