Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.
| Production | Neal H. Moritz | Producer |
| Production | Michael Tadross | Executive Producer |
| Art | Naomi Shohan | Production Design |
| Camera | Andrew Lesnie | Director of Photography |
| Editing | Wayne Wahrman | Editor |
| Production | Erwin Stoff | Executive Producer |
| Directing | Francis Lawrence | Director |
| Writing | Mark Protosevich | Screenplay |
| Writing | Akiva Goldsman | Screenplay |
| Production | James Lassiter | Producer |
| Production | Dana Goldberg | Executive Producer |
| Production | Bruce Berman | Executive Producer |
| Production | David Heyman | Producer |
| Costume & Make-Up | Michael Kaplan | Costume Design |
| Production | Kathleen Chopin | Casting |
| Production | Akiva Goldsman | Producer |
| Visual Effects | Josh LaBrot | Animation |
| Sound | James Newton Howard | Original Music Composer |
| Crew | David Neumann | Choreographer |
| Production | Mohamed Khan | Production Coordinator |
| Production | Tracy Tormé | Co-Producer |
| Production | Jeffrey Wetzel | Co-Producer |
| Art | William Ladd Skinner | Art Direction |
| Camera | David J. Thompson | "B" Camera Operator |
| Camera | Ed Nessen | Additional Second Assistant Camera |
| Visual Effects | Gavin Moran | Animation |
| Visual Effects | Ryan Page | Animation |
| Art | Amiee Clark | Art Department Coordinator |
| Sound | Chris Bacon | Conductor |
| Art | Howard Cummings | Art Direction |
| Art | Patricia Woodbridge | Art Direction |
| Camera | Elizabeth Singer | Camera Loader |
| Visual Effects | Sandra Ryan-Moran | Animation |
| Art | Mark Fitzgibbons | Assistant Art Director |
| Production | Adam Baer | Assistant Location Manager |
| Production | Joshua Shull | Assistant Location Manager |
| Production | Jacq Donegan | Assistant Production Coordinator |
| Camera | Eve Strickman | Camera Production Assistant |
| Editing | Sam Daley | Colorist |
| Art | Lufeng Qu | Concept Artist |
| Directing | Michael Tadross Jr. | Additional Second Assistant Director |
| Production | Caitlin McKenna | ADR Voice Casting |
| Visual Effects | Dougg Williams | Animation |
| Camera | Lukasz Jogalla | Camera Operator |
| Production | Matthew Honovic | Casting Assistant |
| Costume & Make-Up | Brianna Patterson | Costume Assistant |
| Camera | Hans Bjerno | Aerial Director of Photography |
| Visual Effects | Scott Holmes | Animation |
| Camera | Eric P. Robinson | Assistant Camera |
| Costume & Make-Up | Elizabeth Shelton | Assistant Costume Designer |
| Art | Michael Jortner | Assistant Property Master |
| Camera | Keith Bunting | Dolly Grip |
| Crew | Day Ryan | Actor's Assistant |
| Crew | Susan R. Hanson | Animal Wrangler |
| Visual Effects | Joshua Beveridge | Animation |
| Production | Michael Riolo | Art Department Production Assistant |
| Camera | Lance Mayer | Assistant Camera |
| Camera | Benjamin Semanoff | Camera Operator |
| Camera | Tom Weston | Camera Operator |
| Crew | Edward J. Johnson | Carpenter |
| Crew | Yosef Barbalat | Carpenter |
| Editing | Lee Wimer | Color Timer |
| Crew | Ralph Saunders | Actor's Assistant |
| Art | Malchus Janocko | Assistant Art Director |
| Costume & Make-Up | Marian Toy | Assistant Costume Designer |
| Camera | David J. Thompson | Steadicam Operator |
| Production | Carla Lewis | ADR Voice Casting |
| Visual Effects | John Wong | Animation |
| Visual Effects | Ron Smith | Animation |
| Camera | Gregg de Domenico | Assistant Camera |
| Camera | Julian J. Delacruz | Assistant Camera |
| Camera | Craig Pecchia | Camera Production Assistant |
| Art | Jeff Julian | Conceptual Design |
| Crew | Steve Berens | Animal Coordinator |
| Visual Effects | Brian D. Scott | Animation |
| Visual Effects | Sebastian Kapijimpanga | Animation |
| Art | Aaron Sims | Concept Artist |
| Art | George DeTitta Jr. | Set Decoration |
| Crew | Paul Sinor | Thanks |
| Art | Barbra Matis | Assistant Art Director |
| Costume & Make-Up | Leslie Yarmo | Assistant Costume Designer |
| Sound | Grant Gershon | Conductor |
| Camera | Brant S. Fagan | "B" Camera Operator |
| Production | Shannon Cooney | Additional Production Assistant |
| Production | Graham Goetz | Assistant Location Manager |
| Lighting | Bill Almeida | Best Boy Electric |
| Lighting | John Billeci | Best Boy Electric |
| Art | Ed Natividad | Conceptual Design |
| Crew | Carlos Constanzo | Actor's Assistant |
| Production | Chris Kocses | Additional Production Assistant |
| Art | Dan Kuchar | Assistant Art Director |
| Production | Tim Stacker | Assistant Location Manager |
| Art | Tonero Williams | Assistant Property Master |
| Camera | Yueni Zander | Camera Loader |
| Crew | John S. Coda | Carpenter |
| Crew | Philip M. Strub | Thanks |
| Camera | Brant S. Fagan | Steadicam Operator |
| Visual Effects | Dennis Green | 24 Frame Playback |
| Production | Lora Sorrentino | Additional Production Assistant |
| Camera | Bruce MacCallum | "A" Camera Operator |
| Production | Ryan Muir | Additional Production Assistant |
| Production | Damon Michael Gordon | Assistant Location Manager |
| Production | Dan Cooley | Assistant Location Manager |
| Visual Effects | Jacob Patrick | Animation |
| Camera | Brooks P. Guyer | Camera Operator |
| Visual Effects | Jeff Croke | Animation |
| Art | Peter Baran | Assistant Art Director |
| Production | Cristina Lois | Assistant Production Coordinator |
| Production | Kevin Flatow | Assistant Production Manager |
| Crew | Michael Kall | Carpenter |
| Sound | Pete Anthony | Orchestrator |
| Visual Effects | Jerad Marantz | Character Designer |
| Sound | Pete Anthony | Conductor |
| Production | Barbara Harris | ADR Voice Casting |
| Art | Joseph S. Alfieri | Construction Coordinator |
| Visual Effects | Daniel Perez Ferreira | Visual Effects Technical Director |
| Visual Effects | Janek Sirrs | Visual Effects Supervisor |
| Directing | Jeffrey Wetzel | First Assistant Director |
| Crew | Vic Armstrong | Stunt Coordinator |
| Crew | William Cote | Stunts |
| Crew | Jared Burke | Stunts |
| Crew | Mark Chadwick | Stunts |
| Crew | Bob Colletti | Stunts |
| Crew | Jill Brown | Stunts |
| Crew | John Cenatiempo | Stunts |
| Crew | Blaise Corrigan | Stunts |
| Crew | Peter Epstein | Stunts |
| Crew | Christopher Place | Stunts |
| Crew | Thomas Place | Stunts |
| Crew | Tina Mckissick | Stunts |
| Crew | David S. Lomax | Stunts |
| Crew | Gabriel Hansen | Stunts |
| Sound | Armen Ksajikian | Musician |
| Crew | Caroline Vexler | Stunts |
| Crew | Kimberly Shannon Murphy | Stunts |
| Sound | Tom Brown | Music Arranger |
| Crew | Shawnna Thibodeau | Stunts |
| Visual Effects | Hiroshi Mori | Visual Effects |
| Crew | Aja Frary | Stunt Double |
| Crew | Aaron Vexler | Stunts |
| Crew | Jodi Michelle Pynn | Stunts |
| Visual Effects | Patrick Tatopoulos | Creature Design |
| Writing | Richard Matheson | Novel |
| Writing | John William Corrington | Original Film Writer |
| Writing | Joyce Hooper Corrington | Original Film Writer |
