The malevolent inter-dimensional machine is still channeling monsters and blowing minds, but this time things get even more complicated with the arrival of mad med student Herbert West and his dreaded reagent!
| Directing | William Butler | Director |
| Writing | William Butler | Writer |
| Camera | Howard Wexler | Director of Photography |
| Camera | Josh Apple | Second Unit Director of Photography |
| Camera | Thomas Matheis | Steadicam Operator |
| Editing | Topher Hansson | Editor |
| Production | Melissa Vitello | Line Producer |
| Production | Greg Lightner | Associate Producer |
| Production | Josh Apple | Associate Producer |
| Costume & Make-Up | Eric Robinson | Costume Designer |
| Costume & Make-Up | Deanna Ochrin | Wardrobe Assistant |
| Art | Dave Lowe | Special Props |
| Art | Steve Hohman | Construction Coordinator |
| Art | Xavier LS Dellinger | Additional Storyboarding |
| Sound | Richard Band | Music |
| Crew | Rick Butler | Additional Music |
| Crew | Fred Rapoport | Additional Music |
| Sound | Static Music | Music Editor |
| Sound | Kenny Klimak | Sound Designer |
| Sound | Barking Dog Sound | Sound Mixer |
| Production | Jessica Hughes | Casting |
| Production | Houde School of Acting | Casting |
| Costume & Make-Up | Greg Lightner | Special Effects Makeup Artist |
| Crew | Darren Gierowski | Special Effects Assistant |
| Crew | Lee Romaire | Animatronic and Prosthetic Effects |
| Visual Effects | Antonio Mujace | Visual Effects |
| Visual Effects | Dave Matherly | Additional Visual Effects |
| Editing | Jeff Jones | Color Grading |
| Editing | Color Image Post | Color Grading |
| Sound | Chris Meigs | Location Sound Mixer |
| Sound | Jeremy Drazdik | Location Sound Mixer |
| Sound | Jordan Greytak | Location Sound Mixer |
| Camera | Ethan McElwee | Second Assistant Camera |
| Camera | Joe Loszack | Clapper Loader |
| Lighting | Thomas Gavin | Gaffer |
| Production | Izzy Kipling | Production Assistant |
| Costume & Make-Up | Raquel Suarez | Hair Designer |
| Costume & Make-Up | Kristephan Warren | Hair Designer |
| Production | Rosie Hechanova | Location Manager |
| Crew | Bruce Ehleringer | Thanks |
| Crew | Merele Ehleringer | Thanks |
| Crew | Kimberly Williams | Thanks |
| Crew | Jesse Williams | Thanks |
| Crew | Robin Sydney | Thanks |
| Crew | Docherty Talent Agency | Thanks |
| Crew | Howard Berger | Thanks |
| Crew | Zalman Band | Thanks |
| Crew | Michael S. Deak | Thanks |
| Crew | Cleveland Film Commission | Thanks |
| Crew | Daniel Kargle | Thanks |
| Crew | Robert Kurtzman | Thanks |
| Crew | Skinny | Thanks |
| Crew | Mushroom Head | Thanks |
| Crew | Jim Stapley | Thanks |
| Crew | House of Wills | Thanks |
| Crew | Eddie Henry | Thanks |
| Crew | Yogi | Thanks |
| Production | Charles Band | Producer |
| Production | William Butler | Producer |
| Crew | Stuart Gordon | In Memory Of |
| Camera | Mikey Stice | First Assistant Camera |
