An exploration of the United States of America's war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin's sheltered trophy wife must learn her husband's ruthless business after he is arrested, endangering her luxurious lifestyle.
| Writing | Stephen Gaghan | Screenplay |
| Production | Laura Bickford | Producer |
| Editing | Stephen Mirrione | Editor |
| Production | Marshall Herskovitz | Producer |
| Sound | Herbie Hancock | Music |
| Directing | Steven Soderbergh | Director |
| Sound | Cliff Martinez | Original Music Composer |
| Art | Philip Messina | Production Design |
| Writing | Simon Moore | Screenplay |
| Camera | Steven Soderbergh | Director of Photography |
| Art | Keith P. Cunningham | Art Direction |
| Costume & Make-Up | Louise Frogley | Costume Design |
| Production | Debra Zane | Casting |
| Production | Edward Zwick | Producer |
| Costume & Make-Up | Joyce Kogut | Costume Supervisor |
| Costume & Make-Up | Loretta James-Demasi | Makeup Artist |
| Directing | Annie Welles | Script Supervisor |
| Art | Kristen Toscano Messina | Set Decoration |
| Costume & Make-Up | Roxanne Wightman | Hairstylist |
| Art | Chris Snyder | Construction Coordinator |
| Art | Wylie Griffin | Art Department Coordinator |
| Costume & Make-Up | Bonnie Clevering | Hair Department Head |
| Production | Terri Taylor | Casting Associate |
| Costume & Make-Up | Kathrine Gordon | Hair Department Head |
| Costume & Make-Up | Katherine James | Makeup Department Head |
| Sound | Larry Blake | Supervising Sound Editor |
| Sound | Larry Blake | Sound Re-Recording Mixer |
| Crew | Caitlin Maloney | Post Production Supervisor |
| Sound | Aaron Glascock | Dialogue Editor |
| Sound | F. Scott Taylor | Assistant Sound Editor |
| Sound | Alicia Stevenson | Foley Artist |
| Sound | Dawn Fintor | Foley Artist |
| Sound | David Betancourt | Foley Mixer |
| Sound | Rick Mitchell | Foley Editor |
| Sound | John Murray | Foley Editor |
| Editing | Gary Burritt | Negative Cutter |
| Editing | Dana Ross | Color Timer |
| Crew | John Robotham | Stunt Coordinator |
| Camera | Gary Jay | Camera Operator |
| Camera | Barry Idoine | First Assistant "A" Camera |
| Camera | Duane Manwiller | First Assistant "B" Camera |
| Sound | Paul Ledford | Production Sound Mixer |
| Sound | Keenan Wyatt | Boom Operator |
| Sound | Joseph F. Brennan | Boom Operator |
| Production | Robin Le Chanu | Production Supervisor |
| Production | Sonny Ritscher | Production Accountant |
| Art | Blair Huizingh | Assistant Art Director |
| Art | Greg Berry | Set Designer |
| Art | Maya Shimoguchi | Set Designer |
| Art | Barbara Ann Spencer | Set Designer |
| Art | Steven Melton | Property Master |
| Art | Lance Larson | Assistant Property Master |
| Art | Melody Miller | Assistant Property Master |
| Art | Shana Sigmond | Assistant Set Decoration |
| Art | Jason Bedig | Leadman |
| Art | Dale E. Anderson | Set Dresser |
| Art | Brent A. Blom | Set Dresser |
| Art | Gary A. Brewer | Set Dresser |
| Art | Alan Easley | Set Dresser |
| Art | Brooke Sartorius | Set Dresser |
| Camera | James W. Apted | Second Assistant "A" Camera |
| Camera | Glenn Brown | Second Assistant "B" Camera |
| Camera | Stacy De La Motte | Camera Loader |
| Camera | Bob Marshak | Still Photographer |
| Crew | Edward J. Ertel | Projection |
| Lighting | James Plannette | Chief Lighting Technician |
| Lighting | Eric Wycoff | Best Boy Electric |
| Lighting | Russell Ayer | Electrician |
| Lighting | R. Michael De Chellis | Rigging Gaffer |
| Camera | Herb Ault | Key Grip |
| Camera | Kevin 'Rambo' Fitzgerald | Best Boy Grip |
| Camera | Kyle Carden | Grip |
| Directing | Basti Van Der Woude | Second Second Assistant Director |
| Production | Frederic W. Brost | Unit Production Manager |
| Directing | Gregory Jacobs | First Assistant Director |
| Directing | Trey Batchelor | Second Assistant Director |
| Production | Ken Lavet | Location Manager |
| Production | Sonya Lunsford | First Assistant Accountant |
| Production | Renee D. Czarapata | Payroll Accountant |
| Production | Karen Jarnecke | Production Coordinator |
| Production | Pamela Lynn Thomas | Casting Assistant |
| Crew | Rick Avery | Stunts |
| Art | Mike Malone | Set Dresser |
| Production | Cameron Jones | Executive Producer |
| Production | Graham King | Executive Producer |
| Production | Andreas Klein | Executive Producer |
| Production | Mike Newell | Executive Producer |
| Production | Richard Solomon | Executive Producer |
| Crew | Jimmy Ortega | Stunt Double |
