Eddie Murphy stars as shy Dr. Sherman Klump, a kind, brilliant, 'calorifically challenged' genetic professor. When beautiful Carla Purty joins the university faculty, Sherman grows desperate to whittle his 400-pound frame down to size and win her heart. So, with one swig of his experimental fat-reducing serum, Sherman becomes 'Buddy Love', a fast-talking, pumped-up , plumped down Don Juan.
| Writing | Tom Shadyac | Screenplay |
| Production | Karen Kehela Sherwood | Executive Producer |
| Directing | Tom Shadyac | Director |
| Production | Jerry Lewis | Executive Producer |
| Writing | Barry W. Blaustein | Screenplay |
| Production | Mark Lipsky | Executive Producer |
| Editing | Don Zimmerman | Editor |
| Writing | David Sheffield | Screenplay |
| Writing | Steve Oedekerk | Screenplay |
| Camera | Julio Macat | Director of Photography |
| Directing | David B. Householter | First Assistant Director |
| Costume & Make-Up | Beth Miller | Key Hair Stylist |
| Production | Daryl Kass | Unit Production Manager |
| Costume & Make-Up | Ha Nguyen | Costume Design |
| Production | Aleta Chappelle | Casting Director |
| Directing | Daniel M. Stillman | Second Assistant Director |
| Directing | Rebecca Strickland | Second Assistant Director |
| Production | Russell Simmons | Producer |
| Production | Brian Grazer | Producer |
| Costume & Make-Up | Rick Baker | Makeup Effects Designer |
| Art | William A. Elliott | Production Design |
| Art | Kathryn Peters | Set Decoration |
| Production | James D. Brubaker | Co-Producer |
| Sound | David Newman | Original Music Composer |
| Art | Greg Papalia | Art Direction |
| Costume & Make-Up | Geri B. Oppenheim | Key Makeup Artist |
| Production | Tina Fortenberry | Production Supervisor |
| Visual Effects | Robert Stadd | Visual Effects Producer |
| Crew | Mickey Gilbert | Stunt Coordinator |
| Crew | Eugene Collier | Stunts |
| Crew | Tim Gilbert | Stunts |
| Crew | Stanton Barrett | Stunts |
| Crew | Jimmy Lewis Jr. | Stunts |
| Crew | Troy Gilbert | Stunts |
| Crew | Lance Gilbert | Stunts |
| Crew | Joe Finnegan | Stunts |
| Crew | Carlton Holder | Stunts |
| Crew | Bennie Moore | Stunts |
| Crew | Peter Horak | Stunts |
| Crew | Eddie Smith | Stunts |
| Crew | Chuck 'Chaz' Hosack | Stunts |
| Crew | Anthony G. Schmidt | Stunts |
| Crew | Jack Carpenter | Stunts |
| Art | Sally Thornton | Assistant Art Director |
| Crew | Marian Green | Stunts |
| Camera | David E. Diano | "B" Camera Operator |
| Camera | Billy Clevenger | First Assistant "B" Camera |
| Camera | Bruce McBroom | Still Photographer |
| Crew | Paul Murphey | Video Assist Operator |
| Sound | José Antonio García | Sound Mixer |
| Sound | Jonathan Fuh | Boom Operator |
| Crew | Jeff Erdmann | Cableman |
| Directing | Kathryn Weygand | Script Supervisor |
| Production | Gretchen van Zeebroeck | Production Coordinator |
| Production | Maureen Stanton-Leveque | Assistant Production Coordinator |
| Crew | Deborah Simmrin | Unit Publicist |
| Production | Bob Hartman | Payroll Accountant |
| Production | Glen Richard | First Assistant Accountant |
| Production | Laurie Dodsworth | Second Assistant Accountant |
| Lighting | Mike Moyer | Chief Lighting Technician |
| Lighting | Don Nygren | Chief Lighting Technician |
| Lighting | Richard Hartley | Assistant Chief Lighting Technician |
| Lighting | David Burnett | Assistant Chief Lighting Technician |
| Lighting | Ronald Kline | Rigging Gaffer |
| Camera | Gary Dagg | Key Grip |
| Camera | Mike Connors | Dolly Grip |
| Art | James F. Claytor Sr. | Set Designer |
| Art | Yvonne Garnier-Hackl | Set Designer |
| Art | Dawn Snyder | Set Designer |
| Art | Marisol Jiménez | Art Department Coordinator |
| Art | John Maskovich | Leadman |
| Art | Rick Young | Property Master |
| Production | Arlene Kehela | Location Manager |
| Art | Dennis DeWaay | Construction Coordinator |
| Art | Bruce J. Gfeller | Construction Coordinator |
| Crew | Lou Sumien Jr. | Projection |
| Editing | Don Thompson | First Assistant Editor |
| Sound | Steve Maslow | Sound Re-Recording Mixer |
| Sound | Gregg Landaker | Sound Re-Recording Mixer |
| Sound | Michael Hilkene | Supervising Sound Editor |
| Sound | Ed Callahan | Dialogue Editor |
| Sound | Simon Coke | Dialogue Editor |
| Sound | Jeff Rosen | Dialogue Editor |
| Sound | Michael Hilkene | ADR Supervisor |
| Sound | John O. Wilde | Foley Supervisor |
| Sound | Leslie Gaulin | Foley Editor |
| Sound | John T. Cucci | Foley Artist |
| Sound | Dan O'Connell | Foley Artist |
| Sound | James Ashwill | Foley Mixer |
| Production | Barbara Harris | ADR Voice Casting |
| Sound | Jeff Carson | Music Editor |
| Sound | J.J. George | Music Editor |
| Editing | Sandy Brundage | Negative Cutter |
| Editing | Jim Passon | Color Timer |
| Crew | Francine Morris | Stunts |
| Writing | Jerry Lewis | Original Film Writer |
| Writing | Bill Richmond | Original Film Writer |
| Crew | Lane Leavitt | Stunts |
| Editing | Dean Zimmerman | Assistant Editor |
| Camera | David A. Armstrong | First Assistant "C" Camera |
