Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.
| Production | Nobuyuki Iinuma | Producer |
| Writing | Naoki Urasawa | Writer |
| Writing | Yashushi Fukuda | Writer |
| Directing | Yukihiko Tsutsumi | Director |
| Production | Ryûji Ichiyama | Producer |
| Production | Morio Amagi | Producer |
| Production | Futoshi Ohira | Producer |
| Editing | Nobuyuki Ito | Editor |
| Camera | Satoru Karasawa | Director of Photography |
| Production | Seiji Okuda | Executive Producer |
