Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon on the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.
| Sound | Harold Faltermeyer | Original Music Composer |
| Editing | Robert A. Ferretti | Editor |
| Directing | Andrei Konchalovsky | Director |
| Editing | Hubert C. de la Bouillerie | Editor |
| Camera | Donald E. Thorin | Director of Photography |
| Art | Richard Berger | Art Direction |
| Art | David F. Klassen | Art Direction |
| Art | J. Michael Riva | Production Design |
| Production | Larry J. Franco | Co-Producer |
| Production | Peter Guber | Producer |
| Costume & Make-Up | Bernie Pollack | Costume Design |
| Production | Tony Munafo | Associate Producer |
| Production | Peter MacDonald | Executive Producer |
| Production | Jon Peters | Producer |
| Production | Barbara Kalish | Associate Producer |
| Production | Glenn Daniels | Casting |
| Art | Marvin March | Set Decoration |
| Art | Alan S. Kaye | Set Designer |
| Costume & Make-Up | Ed Fincher | Costume Supervisor |
| Crew | Neil Garland | Propmaker |
| Sound | Robert Martel | Assistant Sound Editor |
| Sound | Ed Callahan | Sound Effects Editor |
| Costume & Make-Up | Shirley Dolle | Hairstylist |
| Art | Larry Verne | Construction Coordinator |
| Crew | M. James Arnett | Stunt Coordinator |
| Sound | Carlton Kaller | Music Editor |
| Camera | Daniel C. Gold | First Assistant Camera |
| Lighting | Malcolm Bryce | Lighting Technician |
| Sound | Charles M. Wilborn | Sound Mixer |
| Crew | Gina August | Driver |
| Crew | Paul Murphey | Video Assist Operator |
| Art | Michael Wright | Construction Foreman |
| Lighting | Chris Athy | Electrician |
| Lighting | Gary Molyneux | Rigging Grip |
| Production | Mark L. Roth | Production Accountant |
| Visual Effects | Peter Kuran | Visual Effects |
| Crew | Eddie Lee Voelker | Transportation Captain |
| Art | Sharleen Bright | Standby Painter |
| Sound | Stu Bernstein | Sound Editor |
| Crew | Richie Gaona | Utility Stunts |
| Writing | David Russell | Storyboard |
| Camera | Dave Friedman | Still Photographer |
| Crew | Jeff Winn | Craft Service |
| Art | Kent H. Johnson | Property Master |
| Crew | Mike Sasgen | Carpenter |
| Crew | David Fulton | Unit Publicist |
| Production | Pavel Cerny | Location Manager |
| Camera | Paul E. Borchardt | Key Grip |
| Sound | Michael S. Wren | Sound Recordist |
| Sound | Kenneth Schwarz | Boom Operator |
| Sound | Robert R. Rutledge | Supervising Sound Editor |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Costume & Make-Up | Dennis Liddiard | Makeup Artist |
| Production | Stratton Leopold | Unit Production Manager |
| Art | Jack Eberhart | Leadman |
| Crew | Jon G. Belyeu | Special Effects Coordinator |
| Crew | Steve Hart | Stunts |
| Editing | Stuart Baird | Supervising Editor |
| Writing | Randy Feldman | Writer |
| Camera | Dennis Smith | Camera Operator |
| Camera | Clyde W. Smith | Dolly Grip |
| Crew | Pete Antico | Stunt Double |
| Camera | Michael Raspa | Second Assistant Camera |
| Crew | Dennis Janovici | Vehicles Coordinator |
| Sound | Craig S. Jaeger | Foley Artist |
| Production | Douglas Wright | Casting Coordinator |
| Lighting | Gerald Boatright | Chief Lighting Technician |
| Production | Kathy Sarreal | Production Secretary |
| Crew | David Lea | Technical Advisor |
| Art | Wayne Fitzgerald | Title Designer |
| Production | Peter McManus | Assistant Accountant |
| Lighting | Peter Davidian | Assistant Chief Lighting Technician |
| Sound | Bruce Lacey | ADR Editor |
| Lighting | Richard Ocean | Lighting Design |
| Camera | Charles Hatcher | Best Boy Grip |
| Costume & Make-Up | Leah Brown | Costumer |
| Sound | James Beshears | Supervising ADR Editor |
| Camera | Richard A. Kelley | Assistant Camera |
| Art | Audrey A. Johnson | Assistant Property Master |
| Production | Shirley Cohen | Production Assistant |
| Lighting | Eric Smith | Assistant Chief Lighting Technician |
| Crew | Dick Ziker | Stunts |
| Crew | Jeffrey Hornaday | Choreographer |
| Crew | Jeff Imada | Stunts |
| Crew | Gene LeBell | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Crew | Ronnie Rondell Jr. | Stunts |
| Crew | Mark De Alessandro | Stunt Double |
| Crew | Gary McLarty | Stunts |
| Crew | Bob Orrison | Stunts |
| Crew | Manny Perry | Stunts |
| Crew | Gilbert B. Combs | Stunts |
| Crew | Allan Graf | Stunts |
| Crew | Michael Runyard | Stunts |
| Crew | Dick Warlock | Stunt Double |
| Crew | Charlie Brewer | Stunts |
| Crew | John Casino | Stunts |
| Crew | Joe Gilbride | Stunts |
| Crew | Lila Finn | Stunts |
| Crew | James M. Halty | Stunts |
| Crew | Tommy J. Huff | Stunts |
| Crew | Steve Holladay | Stunts |
| Crew | Freddie Hice | Stunts |
| Crew | Jeff O'Haco | Stunts |
| Crew | Maria R. Kelly | Stunts |
| Crew | Justin De Rosa | Stunts |
| Crew | Mike De Luna | Stunts |
| Crew | Jim Burk | Stunts |
| Crew | Gary Compton | Stunts |
| Crew | Pat Romano | Stunts |
| Crew | J.N. Roberts | Stunts |
| Crew | Ben Scott | Stunts |
| Crew | Steve Vandeman | Stunts |
| Crew | Bill M. Ryusaki | Stunts |
| Crew | Henry Kingi Jr. | Stunts |
| Crew | Robert Apisa | Stunts |
| Crew | Jeff Langton | Stunts |
| Crew | Ron Oliney | Stunts |
| Crew | Jeff Bornstein | Stunts |
| Crew | John-Clay Scott | Stunts |
| Crew | Paul Dion Monte | Stunts |
| Crew | Benny Urquidez | Fight Choreographer |
| Crew | Ric Roman Waugh | Stunts |
| Crew | Rick LeFevour | Stunts |
| Directing | M. James Arnett | Second Unit Director |
| Directing | Marty P. Ewing | First Assistant Director |
| Directing | Artist W. Robinson | Second Assistant Director |
| Directing | Peter MacDonald | Second Unit Director |
| Camera | Julio Macat | Second Unit Director of Photography |
| Lighting | James F. Boyle | Chief Lighting Technician |
| Camera | Frederic J. Smith | Camera Operator |
| Directing | Kathryn Weygand | Script Supervisor |
| Costume & Make-Up | Gary Liddiard | Makeup Artist |
