Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. A retired spy Marissa (Jessica Alba) is thrown back into the action along with her stepchildren when a maniacal Timekeeper (Jeremy Piven) attempts to take over the world. In order to save the world, Rebecca (Rowan Blanchard) and Cecil (Mason Cook) must team up with their hated stepmother. Carmen and Juni have since also grown up and will provide gadgets to them.
| Directing | Robert Rodriguez | Director |
| Camera | Robert Rodriguez | Director of Photography |
| Production | Robert Rodriguez | Producer |
| Writing | Robert Rodriguez | Writer |
| Sound | Robert Rodriguez | Music |
| Production | Bob Weinstein | Executive Producer |
| Production | Harvey Weinstein | Executive Producer |
| Production | Elizabeth Avellan | Producer |
| Production | Mary Vernieu | Casting |
| Editing | Dan Zimmerman | Editor |
| Art | Steve Joyner | Production Design |
| Costume & Make-Up | Nina Proctor | Costume Design |
| Production | George Huang | Co-Producer |
| Production | Bill Scott | Line Producer |
| Production | Rebecca Rodriguez | Co-Producer |
| Sound | Carl Thiel | Music |
| Camera | Jimmy Lindsey | Director of Photography |
| Production | J.C. Cantu | Casting |
| Art | David Hack | Set Decoration |
| Art | Caylah Eddleblute | Production Design |
| Production | Tom Proper | Associate Producer |
| Crew | Jackson Spidell | Stunts |
