The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.
| Production | Vincenzo Natali | Executive Producer |
| Production | Nohuhiko Sakotu | Executive Producer |
| Sound | Michael Andrews | Original Music Composer |
| Camera | Derek Rogers | Director of Photography |
| Writing | Andrew Lowery | Screenplay |
| Directing | Vincenzo Natali | Director |
| Production | Hanno Huth | Executive Producer |
| Production | Steven Hoban | Producer |
| Editing | Michele Conroy | Editor |
| Production | Noah Segal | Executive Producer |
| Writing | Andrew Miller | Screenplay |
| Art | Peter Cosco | Production Design |
| Art | Jasna Stefanovic | Production Design |
| Art | Anastasia Masaro | Art Direction |
| Costume & Make-Up | Alex Kavanagh | Costume Design |
| Writing | Vincenzo Natali | Story |
| Writing | David Hewlett | Story |
| Writing | Andrew Miller | Story |
| Visual Effects | Bob Munroe | Visual Effects Producer |
| Visual Effects | Bret Culp | Visual Effects Supervisor |
| Crew | Paul Rapovski | Stunt Coordinator |
| Crew | Plato Fountidakis | Stunt Coordinator |
| Sound | Stephen Barden | Sound Designer |
| Sound | Stephen Barden | Sound Supervisor |
| Sound | Craig Henighan | Sound Designer |
| Sound | Craig Henighan | Sound Supervisor |
| Sound | Todd Warren | Sound Re-Recording Mixer |
| Production | Paula Devonshire | Line Producer |
| Production | Andrew Lowery | Executive Producer |
| Production | Andrew Miller | Executive Producer |
| Crew | Richard J. Anobile | Post Production Supervisor |
| Directing | Bill Spahic | First Assistant Director |
| Directing | Joanne Tickle | Second Assistant Director |
| Directing | Lisa Burling | Script Supervisor |
| Writing | Ken Chubb | Script Consultant |
| Production | Robin D. Cook | Casting |
| Production | Nicole Hilliard-Forde | Casting |
| Art | Peter Atto | Set Decoration |
| Art | Kent McIntyre | Set Buyer |
| Art | Jon Beer | Set Dresser |
| Art | Craig Harris | Set Dresser |
| Art | Jon Bankson | Construction Coordinator |
| Art | Mark Bryson | Head Carpenter |
| Art | Jay Molloy | Standby Carpenter |
| Crew | Steve Meil | Key Scenic Artist |
| Art | Yassar Monteleone | First Assistant Art Direction |
| Art | Dan Milligan | Storyboard Artist |
| Production | Kimberly Killam | Production Accountant |
| Art | Mark Hunter | Props |
| Art | Peter Miskimmin | Props |
| Camera | Sean Jensen | Steadicam Operator |
| Camera | Sean Jensen | Camera Operator |
| Costume & Make-Up | Midori Nagai | Costume Set Supervisor |
| Camera | Rob Mountjoy | First Assistant Camera |
| Camera | Tara Dixit | Second Assistant Camera |
| Camera | Sean Moore | Camera Trainee |
| Camera | Pief Weyman | Still Photographer |
| Lighting | Jeremy Hudspith | Gaffer |
| Lighting | Derek Porter | Best Boy Electric |
| Lighting | David Riding | Electrician |
| Lighting | Scott Tremblay | Electrician |
| Camera | Eric Berger | Key Grip |
| Camera | Carl Savage | Dolly Grip |
| Camera | Jeff Wachsmann | Best Boy Grip |
| Camera | John MacLean | Grip |
| Sound | Steven Bourne | Sound Recordist |
| Sound | Jorge Muniz | Boom Operator |
| Sound | Kelly Wright | Sound Recordist |
| Crew | Michael Sinnott | Stunt Double |
| Crew | Neil Davison | Stunt Double |
| Costume & Make-Up | Barb Barkley | Key Makeup Artist |
| Costume & Make-Up | Katrin Clark | Key Hair Stylist |
| Crew | John LaForet | Special Effects Coordinator |
| Costume & Make-Up | Allan Cooke | Makeup Effects Designer |
| Costume & Make-Up | Paul Jones | Makeup Effects Designer |
| Costume & Make-Up | Patrick Baxter | Special Effects Makeup Artist |
| Costume & Make-Up | Matthew Galliford | Special Effects Makeup Artist |
| Costume & Make-Up | Gérald Altenburg | Special Effects Makeup Artist |
| Crew | Mark Ahee | Key Special Effects |
| Crew | Kirk Middleton | Special Effects |
| Production | Jason McKenzie | Production Coordinator |
| Directing | Siegfried Kopp | Third Assistant Director |
| Production | Michael Bawcutt | Assistant Production Coordinator |
| Production | Rita Bertucci | Extras Casting |
| Crew | Rick Parker | Animal Wrangler |
| Crew | Matthew Spahic | Animal Wrangler |
| Production | Beverly Warren | Publicist |
| Production | Monica Ionson | Assistant Accountant |
| Production | John Temou | Location Manager |
| Production | Mauro Sepe | Assistant Location Manager |
| Production | Dave Herchenrader | Location Production Assistant |
| Visual Effects | Steve Angel | Animation Director |
| Visual Effects | Julian Grey | Animation Director |
| Camera | Kevin Murphy | Second Unit Director of Photography |
| Sound | Stephen Barden | Dialogue Editor |
| Sound | Jill Purdy | ADR Editor |
| Sound | Kevin Banks | Music Editor |
| Sound | Alex Bullick | First Assistant Sound Editor |
| Sound | John Sievert | Foley Artist |
| Sound | Peter Persaud | Foley Recordist |
| Sound | Gina Gyles | Assistant Foley Artist |
| Sound | Andrew Tay | Sound Re-Recording Mixer |
| Sound | Christian Carruthers | Sound Re-Recording Mixer |
| Sound | Matthew McKenzie | ADR Recordist |
| Sound | Colin McLellan | ADR Recordist |
| Sound | Jamie Gould | Sound Re-Recording Assistant |
| Editing | Kenn Elliott | Colorist |
| Editing | Mike Dubroskie | Colorist |
