A sorority moves in next door to the home of Mac and Kelly Radner who have a young child. The Radner's enlist their former nemeses from the fraternity to help battle the raucous sisters.
| Directing | Nicholas Stoller | Director |
| Writing | Andrew J. Cohen | Writer |
| Writing | Evan Goldberg | Writer |
| Writing | Brendan O'Brien | Writer |
| Writing | Seth Rogen | Writer |
| Writing | Nicholas Stoller | Writer |
| Production | Nathan Kahane | Executive Producer |
| Production | Ted Gidlow | Executive Producer |
| Production | Andrew J. Cohen | Executive Producer |
| Production | Brendan O'Brien | Executive Producer |
| Production | Seth Rogen | Producer |
| Production | Evan Goldberg | Producer |
| Production | James Weaver | Producer |
| Writing | Andrew J. Cohen | Characters |
| Writing | Brendan O'Brien | Characters |
| Art | Theresa Guleserian | Production Design |
| Editing | Zene Baker | Editor |
| Costume & Make-Up | Leesa Evans | Costume Design |
| Sound | Michael Andrews | Original Music Composer |
| Production | Francine Maisler | Casting |
| Production | Kathy Driscoll-Mohler | Casting |
| Sound | Manish Raval | Music Supervisor |
| Sound | Tom Wolfe | Music Supervisor |
| Production | Ted Gidlow | Unit Production Manager |
| Camera | Brandon Trost | Director of Photography |
| Production | Joseph Drake | Executive Producer |
| Art | Cate Bangs | Art Direction |
| Art | Ryan Watson | Set Decoration |
| Costume & Make-Up | Maggie Fung | Makeup Department Head |
| Sound | Michael Babcock | Sound Re-Recording Mixer |
| Sound | Michael Babcock | Supervising Sound Editor |
| Sound | Jeff Sawyer | Sound Effects Editor |
| Sound | Randy Torres | Sound Effects Editor |
| Editing | Michael A. Webber | Editor |
| Production | Erin Westerman | Co-Producer |
| Production | Josh Fagen | Co-Producer |
| Production | Kyle Hunter | Co-Producer |
| Production | Ariel Shaffir | Co-Producer |
| Directing | Michael J. Moore | First Assistant Director |
| Directing | Matt Haggerty | Second Assistant Director |
| Crew | Jeffrey J. Dashnaw | Stunt Coordinator |
| Crew | Jamal Sims | Choreographer |
| Production | Maria Blasucci | Associate Producer |
| Production | Amanda Lund | Associate Producer |
| Production | Douglas I. Schwartz | Associate Producer |
| Art | Patricia Klawonn | Set Designer |
| Art | John Thigpen | Set Designer |
| Costume & Make-Up | Heather Kane | On Set Dresser |
| Costume & Make-Up | Ellen Arden | Makeup Artist |
| Costume & Make-Up | Robert Satkovich | Makeup Artist |
| Costume & Make-Up | Colleen LaBaff | Hair Department Head |
| Directing | Alicia Accardo | Script Supervisor |
| Sound | Tony Lamberti | Sound Re-Recording Mixer |
| Editing | Doug Delaney | Digital Intermediate Colorist |
| Camera | Blake Hooks | Second Assistant "B" Camera |
