Ellen Burton arrives in Africa to join Dr. Mary as her nurse, bringing modern medicine to the native peoples. Lonni Douglas, an animal wrangler and fortune hunter, agrees to take her upriver, despite his misgivings about her suitability for Africa. They battle escaped gorillas, hostile natives, infected lion wounds, and hostile witch doctors to reach their destination and on the way, they fall in love. Will their contrasting interests doom their romance?
| Directing | Henry Hathaway | Director |
| Writing | Ben Roberts | Screenplay |
| Writing | Ivan Goff | Screenplay |
| Writing | Louise A. Stinetorf | Novel |
| Production | Otto Lang | Producer |
| Sound | Bernard Herrmann | Original Music Composer |
| Editing | James B. Clark | Editor |
| Camera | Leon Shamroy | Director of Photography |
| Art | Lyle R. Wheeler | Art Direction |
| Art | Mark-Lee Kirk | Art Direction |
| Art | Stuart A. Reiss | Set Decoration |
| Costume & Make-Up | Ben Nye | Makeup Artist |
| Costume & Make-Up | Dorothy Jeakins | Costume Design |
| Directing | Gerd Oswald | First Assistant Director |
| Directing | Arthur Lueker | First Assistant Director |
| Directing | Richard Rosson | Second Unit Director |
| Directing | Erich von Stroheim Jr. | Assistant Director |
| Sound | Harry M. Leonard | Sound |
| Sound | Eugene Grossman | Sound |
| Visual Effects | Ray Kellogg | Visual Effects |
| Camera | Harry Jackson | Second Unit Director of Photography |
| Camera | Charles G. Clarke | Second Unit Director of Photography |
| Camera | Joseph MacDonald | Additional Director of Photography |
| Directing | Eva Monley | Script Supervisor |
