Six years after the events of The X-Files series finale, former FBI agent Doctor Dana Scully is now a staff physician at Our Lady of Sorrows, a Catholic hospital, and treating a boy named Christian who has Sandhoff disease, a terminal brain condition. FBI agent Drummy arrives to ask Scully’s help in locating Fox Mulder, the fugitive former head of the X-Files division, and says they will call off its manhunt for him if he will help investigate the disappearances of several women, including young FBI agent Monica Banan. Mulder and Scully are called back to duty by the FBI when a former priest claims to be receiving psychic visions pertaining to a kidnapped agent.
| Directing | Chris Carter | Director |
| Writing | Chris Carter | Screenplay |
| Writing | Frank Spotnitz | Screenplay |
| Production | Chris Carter | Producer |
| Sound | Mark Snow | Original Music Composer |
| Camera | Bill Roe | Director of Photography |
| Editing | Richard A. Harris | Editor |
| Production | Heike Brandstatter | Casting |
| Production | Mindy Marin | Casting |
| Production | Coreen Mayrs | Casting |
| Art | Mark S. Freeborn | Production Design |
| Art | Tony Wohlgemuth | Art Direction |
| Art | Shirley Inget | Set Decoration |
| Costume & Make-Up | Lisa Tomczeszyn | Costume Design |
| Costume & Make-Up | Victoria Down | Makeup Department Head |
| Costume & Make-Up | Sandy Monesmith | Hairstylist |
| Crew | Julio Pallares | Makeup Effects |
| Crew | Christopher Mark Pinhey | Makeup Effects |
| Crew | Bill Terezakis | Makeup Effects |
| Crew | Maureen Terezakis | Makeup Effects |
| Production | Simon Abbott | Production Manager |
| Production | Wayne Bennett | Production Manager |
| Crew | David McKimmie | Post-Production Manager |
| Production | Brent O'Connor | Unit Production Manager |
| Crew | Paul Rabwin | Post Production Supervisor |
| Crew | E. J. Foerster | Second Unit |
| Costume & Make-Up | Jared Brown | Set Dressing Artist |
| Costume & Make-Up | Raul Casillas | Set Dressing Artist |
| Costume & Make-Up | Geoff Coulter | Set Dressing Artist |
| Art | David Hadaway | Set Designer |
| Costume & Make-Up | Scott Holburn | Set Dressing Artist |
| Costume & Make-Up | Leonardo Lara | Set Dressing Artist |
| Art | Cheryl Marion | Assistant Art Director |
| Costume & Make-Up | Mark Prior | Set Dressing Artist |
| Art | Mike Rennison | Construction Coordinator |
| Art | Paul Rinaldi | Construction Foreman |
| Art | Sabine Schoppel | Art Department Coordinator |
| Writing | Jenny Seinen | Storyboard |
| Sound | David Betancourt | Foley |
| Sound | David Giammarco | Sound Re-Recording Mixer |
| Sound | David Grimaldi | Sound Effects Editor |
| Sound | Randall Guth | First Assistant Sound Editor |
| Sound | Warren Hendriks | Sound Effects Editor |
| Sound | Martin Lacroix | Boom Operator |
| Sound | David Lucarelli | ADR & Dubbing |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Sound | Chuck Michael | Sound Designer |
| Sound | Erin Michael Rettig | Sound Engineer |
| Sound | Charleen Richards-Steeves | ADR & Dubbing |
| Sound | Alicia Stevenson | Foley |
| Crew | William Unrau | Cableman |
| Crew | David Gauthier | Special Effects Coordinator |
| Crew | David Alexander | CG Supervisor |
| Crew | Rodrigo Armendariz | Compositors |
| Visual Effects | Steve Au | CG Painter |
| Crew | Michel Barrière | Compositors |
| Visual Effects | Mat Beck | Visual Effects Supervisor |
| Crew | Charles Collyer | Compositors |
| Visual Effects | Glenn Curry | CG Painter |
| Visual Effects | Anouk Deveault-Moreau | Visual Effects Supervisor |
| Crew | Linda Drake | Visual Effects Editor |
| Crew | Jason Dunn | Compositors |
| Crew | Andrew Edwards | Compositors |
| Crew | Ryan Epp | Compositors |
| Visual Effects | Thomas F. Ford IV | Visual Effects Producer |
| Crew | Mark Goldberg | Compositors |
| Crew | Don Greenberg | Compositors |
| Visual Effects | Junji Hirano | CG Painter |
| Visual Effects | Graham Houston | CG Painter |
| Visual Effects | Brenda Ilic | Visual Effects Producer |
| Visual Effects | Joni Jacobson | Visual Effects Producer |
| Visual Effects | Daniel Leduc | Visual Effects Producer |
| Visual Effects | Andrew Lema | CG Painter |
| Crew | Matthias Lowry | Compositors |
| Crew | Richard Martin | Compositors |
| Visual Effects | Jack Noriaki Matsumoto | CG Painter |
| Crew | Steve J. McLeod | Compositors |
| Crew | Vinay Mehta | Compositors |
| Visual Effects | Tena Montoya | Visual Effects Producer |
| Visual Effects | Eugene Paluso | CG Painter |
| Visual Effects | Rod Park | Visual Effects Producer |
| Crew | Brian Petras | Compositors |
| Crew | Pierre Raymond | Executive Visual Effects Producer |
| Production | Dan Rucinski | Production Supervisor |
| Crew | Brian Sales | Compositors |
| Visual Effects | Andrea Shear | CG Painter |
| Crew | Wayne A. Shepherd | Compositors |
| Visual Effects | Randal Shore | Visual Effects Producer |
| Visual Effects | Trent Smith | Visual Effects Producer |
| Crew | Christina Spring | Compositors |
| Crew | Mike Spring | Compositors |
| Crew | Marty Taylor | Compositors |
| Crew | Patrick Thompson | Compositors |
| Production | Anne Tremblay | Administration |
| Crew | Donald Tse | Compositors |
| Visual Effects | Dmitry Vinnik | CG Painter |
| Visual Effects | John C. Wash | Visual Effects Supervisor |
| Crew | Dave Williams | Compositors |
| Visual Effects | Ian Wilson | CG Painter |
| Crew | Chris Atkinson | Stunts |
| Crew | James Bamford | Stunts |
| Crew | Guy Bews | Stunts |
| Crew | Kimberly Chiang | Stunts |
| Crew | Duane Dickinson | Stunts |
| Crew | Mike Dobbin | Stunts |
| Crew | Bill Edwards | Stunts |
| Crew | Corbin Fox | Stunts |
| Crew | Dean Hart | Stunts |
| Crew | Dave Lane | Stunts |
| Crew | Mike Mitchell | Stunt Coordinator |
| Crew | Tony Morelli | Stunts Coordinator |
| Crew | Jennifer Mylrea | Stunts |
| Crew | Jeff Sanca | Stunts |
| Crew | Todd Scott | Stunts |
| Crew | Melissa R. Stubbs | Stunts |
| Crew | Natasha Vasiluk | Stunts |
| Crew | Marshall Virtue | Stunts |
| Crew | Chris Webb | Stunts |
| Camera | Matt Almas | Grip |
| Lighting | Ryan Bailey | Gaffer |
| Camera | Mitch Bax | Camera Intern |
| Crew | George Collins | Video Assist Operator |
| Costume & Make-Up | Gitte Axen | Makeup Artist |
| Production | Brent O'Connor | Executive Producer |
| Production | Frank Spotnitz | Producer |
| Art | Wayne McLaughlin | Property Master |
| Art | Marta McLaughlin | Assistant Property Master |
| Art | Eric Partridge | Assistant Property Master |
| Art | Brad McMurray | Set Decorating Coordinator |
| Camera | John S. Bartley | Second Unit Director of Photography |
| Camera | Cory Budney | First Assistant Camera |
| Sound | Dennis Rogers | Sound Recordist |
| Sound | Tim Gomillion | Sound Recordist |
| Directing | Portia Tickell | Script Supervisor |
| Sound | Gloria D'Alessandro | Dialogue Editor |
| Sound | Mildred Iatrou | ADR Editor |
| Sound | Scott Curtis | Foley Editor |
| Sound | Matthew Harrison | Foley Editor |
| Sound | Galen Goodpaster | Assistant Sound Editor |
| Sound | Eric A. Larsen | Assistant Sound Editor |
| Sound | Smokey Cloud | Assistant Sound Editor |
| Sound | Michael T. Williamson | Sound Mixer |
| Visual Effects | Bryce Brecheisen | Visual Effects Coordinator |
| Visual Effects | Shane Strickman | Visual Effects Coordinator |
| Production | Mark Sweatman | Production Assistant |
| Crew | Charles Andre | Stunts |
