Scientist Dr. Bradford Crane and army general Thalius Slater join forces to fight an almost invisible enemy threatening America; killer bees that have deadly venom and attack without reason. Disaster movie-master Irwin Allen's film contains spectacular special effects, including a train crash caused by the eponymous swarm.
| Writing | Stirling Silliphant | Screenplay |
| Directing | Irwin Allen | Director |
| Writing | Arthur Herzog III | Novel |
| Art | Stan Jolley | Production Design |
| Production | Irwin Allen | Producer |
| Editing | Harold F. Kress | Editor |
| Camera | Fred J. Koenekamp | Director of Photography |
| Production | Jack Baur | Casting |
| Costume & Make-Up | Paul Zastupnevich | Costume Design |
| Sound | Jerry Goldsmith | Original Music Composer |
| Art | Stuart A. Reiss | Set Decoration |
| Production | Norman A. Cook | Production Manager |
| Costume & Make-Up | Ruby Ford | Hairstylist |
| Crew | George E. Swink | Post Production Supervisor |
| Visual Effects | L.B. Abbott | Visual Effects |
| Costume & Make-Up | Tony Lloyd | Makeup Artist |
| Crew | Howard Jensen | Special Effects |
| Crew | Ernie F. Orsatti | Stunts |
| Crew | Loren Janes | Stunts |
| Crew | Larry Holt | Stunts |
