The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.
| Production | Roy William Neill | Producer |
| Directing | Roy William Neill | Director |
| Editing | Ray Snyder | Editor |
| Art | John B. Goodman | Art Direction |
| Camera | Virgil Miller | Director of Photography |
| Writing | Bertram Millhauser | Writer |
| Art | Martin Obzina | Art Direction |
| Writing | Arthur Conan Doyle | Original Story |
| Sound | Bernard B. Brown | Sound Director |
| Art | Russell A. Gausman | Set Decoration |
| Art | Edward R. Robinson | Set Decoration |
| Costume & Make-Up | Vera West | Costume Design |
| Sound | Paul Sawtell | Original Music Composer |
| Sound | Paul Sawtell | Music Director |
| Production | Howard Benedict | Executive Producer |
