"The Mystery Cruise" centers around best friends and impending business partners, Alvirah Meehan (Gail O'Grady), a lottery winner turned amateur sleuth, and Regan Reilly (Michelle Harrison), a private investigator. After rescuing the diamond-collared pooch of a wealthy socialite (Carol Higgins Clark), the two heroines set off with their spouses to join Regan's mom, Nora Reilly (Colleen Winton), a world famous mystery writer, on a luxurious three day cruise around the San Juan Island off the coast of Washington. The cruise serves as the setting for a mystery game created to promote the release of Nora's latest book. As the boat calmly sets sail, everyone is enjoying getting into character, especially Alvirah, who may or may not be the games "murderess." But troubled waters lie ahead when Alvirah gets a hunch that a real killer may be on board and, together with Regan, the pair teams up to solve the high seas whodunnit.
| Directing | Douglas Barr | Director |
| Writing | Carol Higgins Clark | Book |
| Writing | Mary Higgins Clark | Book |
| Production | Randy Cheveldave | Producer |
| Sound | Claude Foisy | Original Music Composer |
| Camera | Peter Benison | Director of Photography |
| Art | Ester Bovard | Set Decoration |
| Costume & Make-Up | Patricia Hargreaves | Costume Design |
| Costume & Make-Up | Tara Colledge | Key Hair Stylist |
| Costume & Make-Up | Jenine Lehfeldt | Makeup Department Head |
| Directing | Matthias Mellinghaus | First Assistant Director |
| Art | Cameron Boon | Painter |
| Art | Baron Shaver | Construction Coordinator |
| Sound | James Fonnyadt | Sound Designer |
| Sound | Ryan Schaad | Sound Editor |
| Visual Effects | Fred Raimondi | Visual Effects Supervisor |
| Crew | Danny Virtue | Stunt Coordinator |
| Camera | Michelle Faye Fraser | Still Photographer |
| Camera | Chris Large | Still Photographer |
| Production | Mick Rochon | Location Manager |
| Directing | Sandra Montgomery | Script Supervisor |
| Crew | Krista Bell | Stunt Double |