In eighteenth-dynasty Egypt, Sinuhe, a poor orphan, becomes a brilliant physician and with his friend Horemheb is appointed to the service of the new Pharoah. Sinuhe's personal triumphs and tragedies are played against the larger canvas of the turbulent events of the 18th dynasty. As Sinuhe is drawn into court intrigues he learns the answers to the questions he has sought since his birth.
| Directing | Michael Curtiz | Director |
| Writing | Philip Dunne | Screenplay |
| Writing | Casey Robinson | Screenplay |
| Writing | Mika Waltari | Novel |
| Production | Darryl F. Zanuck | Producer |
| Camera | Leon Shamroy | Director of Photography |
| Editing | Barbara McLean | Editor |
| Art | George W. Davis | Art Direction |
| Art | Lyle R. Wheeler | Art Direction |
| Art | Paul S. Fox | Set Decoration |
| Art | Walter M. Scott | Set Decoration |
| Costume & Make-Up | Ben Nye | Makeup Artist |
| Sound | Alfred Newman | Original Music Composer |
| Sound | Bernard Herrmann | Original Music Composer |
| Production | Gertrude Kingston | Research Assistant |
| Production | Frances C. Richardson | Researcher |
