Set against the backdrop of the prescription drug and opioid crisis in the USA, Jamie Sisley depicts the individual consequences of a societal tragedy, while taking an unflinching yet gentle look at a complicated web of relationships.
| Directing | Jamie Sisley | Director |
| Writing | Jamie Sisley | Screenplay |
| Production | Shrihari Sathe | Producer |
| Production | Eric Schultz | Producer |
| Production | Chris Columbus | Executive Producer |
| Production | Eleanor Columbus | Executive Producer |
| Production | Nancy Stephens | Executive Producer |
| Production | Rick Rosenthal | Executive Producer |
| Production | Nion McEvoy | Executive Producer |
| Production | Jennifer Westin | Executive Producer |
| Production | Hannah Pillemer | Executive Producer |
| Production | Fernando Szew | Executive Producer |
| Production | Heidi Castelein | Executive Producer |
| Production | Adam Kirszner | Executive Producer |
| Production | Ozo Jaculewicz | Executive Producer |
| Production | Barbara Perry | Executive Producer |
| Production | Yoshinobu Tsuji | Executive Producer |
| Production | Shannon Akegarasu | Executive Producer |
| Production | Saaz Haque | Executive Producer |
| Production | Rob Cristiano | Co-Producer |
| Production | Stephen Decroes | Co-Executive Producer |
| Production | Lyle Friedman | Associate Producer |
| Production | Meryl Goldsmith | Co-Executive Producer |
| Production | Sarah Dorman Sveen | Co-Producer |
| Production | Alvaro R. Valente | Co-Producer |
| Production | Chrissy Metz | Executive Producer |
| Sound | Ben Sollee | Original Music Composer |
| Camera | Alejandro Mejía | Director of Photography |
| Editing | Alan Canant | Editor |
| Production | Rebecca Birstock | Casting |
| Production | Amy Lippens | Casting |
| Production | Amy Lippens | Co-Producer |
| Art | Caity Birmingham | Production Design |
| Art | Dana Weintraub | Set Decoration |
| Costume & Make-Up | Desira Pesta | Costume Design |
| Costume & Make-Up | Breeanna Nichols | Hair Department Head |
| Costume & Make-Up | Breeanna Nichols | Makeup Department Head |
| Directing | Andrew Harrington | First Assistant Director |
| Directing | Eric Schultz | Second Unit Director |
| Directing | Anne Troup | Second Assistant Director |
| Art | Alex Mastoon | Set Dresser |
| Art | Zachary Mastoon | Set Dresser |
| Sound | Ryan Price | Sound Re-Recording Mixer |
| Sound | José R. Ramírez | Production Sound Mixer |
| Sound | Arjun Sheth | Supervising Sound Editor |
| Visual Effects | Alex Noble | Visual Effects Supervisor |
| Lighting | Colin Chiucchini | Gaffer |
| Crew | Aaron Vexler | Stunts |