A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
| Directing | Bobby Farrelly | Director |
| Writing | Marc Hyman | Screenplay |
| Production | Bobby Farrelly | Producer |
| Production | Peter Farrelly | Producer |
| Production | Zak Penn | Producer |
| Production | Bradley Thomas | Producer |
| Sound | Randy Edelman | Original Music Composer |
| Camera | Mark Irwin | Director of Photography |
| Editing | Lois Freeman-Fox | Editor |
| Editing | Stephen Schaffer | Editor |
| Editing | Sam Seig | Editor |
| Directing | Peter Farrelly | Director |
| Visual Effects | Steven Burch | Special Effects Supervisor |
| Visual Effects | Adam Beck | Animation |
| Visual Effects | Paul Dutton | Animation |
| Directing | Audrey Stedman | Layout |
| Directing | Karen Hamrock | Layout |
| Writing | Bob Camp | Storyboard |
| Directing | Jennifer Yuan | Layout |
| Production | Marc S. Fischer | Co-Producer |
| Production | Aaron Parry | Associate Producer |
| Production | John Walker | Associate Producer |
| Art | Arlan Jay Vetter | Art Direction |
| Visual Effects | Chris Aguirre | Visual Development |
| Writing | Mark Andrews | Storyboard |
| Writing | Barry Caldwell | Storyboard |
| Visual Effects | Ruben Chavez | Visual Development |
| Art | Katherine C. Concepcion | Art Department Manager |
| Visual Effects | Ricardo F. Delgado | Visual Development |
| Visual Effects | Hani D. El-Masri | Visual Development |
| Visual Effects | Jeff Etter | Visual Development |
| Writing | Steve Fonti | Storyboard |
| Visual Effects | Darek Gogol | Visual Development |
| Writing | Daan Jippes | Storyboard |
| Visual Effects | Kevin Johnson | Visual Development |
| Crew | Leon Delaney | Stunt Coordinator |
| Crew | John Bermudes | Special Effects |
| Crew | John Harajovic | Special Effects |
| Crew | William 'Billy Jack' Jakielaszek | Special Effects Coordinator |
| Art | Carol Koch | Sculptor |
| Visual Effects | Craig R. Maras | Animation |
| Crew | Jeannine Berger | Post Production Supervisor |
| Visual Effects | Eddie Rosas | Animation |
| Directing | Bill Perkins | Layout |
| Visual Effects | Earl A. Hibbert | Visual Effects |
| Visual Effects | Randy Sanchez | Animation |
| Directing | James P. Alles | Layout |
| Visual Effects | John Williamson | Animation |
| Visual Effects | Joe Giampapa | Animation |
| Visual Effects | Sam Chou | Animation |
| Visual Effects | Shane Prigmore | Animation |
| Visual Effects | Fred Cline | Visual Development |
| Visual Effects | Ian Mah | Visual Effects Supervisor |
| Crew | Darlie Brewster | Supervising Animator |
| Production | Rick Montgomery | Casting |
| Art | Sydney J. Bartholomew Jr. | Production Design |
| Art | Scott Jacobson | Set Decoration |
| Costume & Make-Up | Pamela Withers | Costume Design |
| Costume & Make-Up | Brenda McNally | Hair Department Head |
| Costume & Make-Up | Joe Rossi | Makeup Department Head |
| Visual Effects | Stephan Franck | Lead Animator |
| Directing | Hal Olofsson | First Assistant Director |
| Sound | Ken Ross | Music Supervisor |
| Sound | Randy Thom | Sound Designer |
| Production | Dennis Edwards | Producer |
| Directing | Louis Gonzales | Layout |
| Art | Moroni Taylor | Storyboard Artist |
| Crew | Alan J. Hagge | Systems Administrators & Support |
