The movie of Natsume's Book of Friends series. Natsume has been busy, navigating between humans and Yokai when he coincidentally reunites with an old classmate, Yuki. It brings back painful memories of a certain Yokai. Meanwhile, Natsume also became acquainted with Yorie Tsumura, a woman in the memories of a Yokai whose name he had returned. Yorie knew much about Reiko, but now lived a peaceful life with her only son, Mukuo. Being with this family was comforting for Natsume, but apparently a mysterious Yokai has been lurking in their town. On the way back from investigating, a "Yokai seed" that had latched itself to Nyanko Sensei drops into the Fujiwaras' garden and grows overnight into a fruit tree. When Nyanko Sensei eats a fruit that is somehow shaped like himself, he suddenly splits into three!
| Writing | Sadayuki Murai | Screenplay |
| Directing | Takahiro Omori | Director |
| Sound | Makoto Yoshimori | Original Music Composer |
| Writing | Yuki Midorikawa | Comic Book |
| Visual Effects | Akira Takata | Character Designer |
| Art | Yukihiro Shibutani | Art Direction |
| Visual Effects | Hideyuki Motohashi | Key Animation |
| Directing | Hideki Ito | Director |
| Visual Effects | Ena Nishikawa | Animation Director |
| Visual Effects | Tomomi Shimazaki | Key Animation |
| Directing | Miyuki Ooshiro | Director |
| Visual Effects | Miyuki Ooshiro | Animation Director |
| Art | Miyuki Ooshiro | Storyboard Artist |
| Visual Effects | Natsuko Kondou | Animation Director |
| Visual Effects | Orie Tanaka | Animation Director |
| Visual Effects | Orie Tanaka | Key Animation |
| Visual Effects | Madoka Katto | Key Animation |
| Production | Noriko Iwasaki | Associate Producer |
