The story is set in 2027, one year after the end of the fourth non-nuclear war. New Port City is still reeling from the war's aftermath when it suffers a bombing caused by a self-propelled mine. Then, a military member implicated in arms-dealing bribes is gunned down. During the investigation, Public Security Section's Daisuke Aramaki encounters Motoko Kusanagi, the cyborg, wizard-level hacker assigned to the military's 501st Secret Unit. Batou, a man with the "eye that does not sleep," suspects that Kusanagi is the one behind the bombing. The Niihama Prefectural Police detective Togusa is pursuing his own dual cases of the shooting death and a prostitute's murder. Motoko herself is being watched by the 501st Secret Unit's head Kurutsu and cyborg agents.
| Production | Mitsuhisa Ishikawa | Executive Producer |
| Art | Yusuke Takeda | Art Direction |
| Directing | Kazuchika Kise | Director |
| Visual Effects | Kazuchika Kise | Character Designer |
| Crew | Masamune Shirow | Creator |
| Editing | Junichi Uematsu | Editor |
| Production | Satoshi Kohno | Production Supervisor |
| Directing | Masahiko Murata | Director |
| Writing | Masahiko Murata | Storyboard |
| Production | Katsuji Morishita | Production Supervisor |
| Crew | Masahiro Murakami | Special Effects |
| Visual Effects | Tetsuya Nishio | Animation Director |
| Visual Effects | Tetsuya Nishio | Character Designer |
| Writing | Tow Ubukata | Screenplay |
| Crew | Tow Ubukata | Compositors |
| Sound | Yoshikazu Iwanami | Sound Director |
| Production | Shirō Sasaki | Production Supervisor |
| Sound | Keigo Oyamada | Original Music Composer |
| Sound | Keigo Oyamada | Main Title Theme Composer |
| Production | Takuya Matsushita | Executive Producer |
| Camera | Koji Tanaka | Director of Photography |
| Production | Shinjiro Yokoyama | Executive Producer |
| Art | Naoki Arakawa | Background Designer |
| Art | Naoki Arakawa | Props |
| Production | Yoshihiro Furusawa | Producer |
| Production | Keiji Ota | Production Supervisor |
| Visual Effects | Takayuki Yanase | Mechanical Designer |
| Production | Tomohisa Nishimura | Producer |
| Visual Effects | Eiji Inomoto | CGI Director |
| Production | Ken Okawara | Producer |
| Art | Takamasa Masuki | Art Direction |
| Production | Jun'ichirō Tsuchiya | Producer |
| Sound | Yoshimoto Ishikawa | Music Producer |
| Production | Hideji Kaneko | Production Supervisor |
| Production | Kimikazi Ueyama | Executive Producer |
| Production | Tôru Kawaguchi | Producer |
| Production | Kengo Abe | Producer |
| Production | Mitsutoshi Arimoto | Producer |
