With the Gyaos re-emerging, Gamera's ties to humanity have been severed with his bond to Asagi broken. Nagamine and Asagi investigate while an orphaned girl named Ayana discovers a new creature she names Iris. Nagamine and Asagi must reach Ayana before she takes her revenge on Gamera, who she blames for the death of her family.
| Directing | Shusuke Kaneko | Director |
| Writing | Shusuke Kaneko | Writer |
| Writing | Kazunori Ito | Writer |
| Sound | Kow Otani | Original Music Composer |
| Editing | Isao Tomita | Editor |
| Art | Hajime Oikawa | Production Design |
| Production | Miyuki Nanri | Producer |
| Production | Naoki Sato | Producer |
| Production | Yasuyoshi Tokuma | Producer |
| Production | Tsutomu Tsuchikawa | Producer |
| Camera | Junichi Tozawa | Director of Photography |
| Visual Effects | Shinji Higuchi | Visual Effects Director |
| Visual Effects | Satoshi Murakawa | Visual Effects Camera |
| Visual Effects | Toshio Miike | Visual Effects Designer |
| Crew | Hiroshi Okuda | Visual Effects Editor |
| Crew | Makoto Kamiya | Special Effects Assistant |
| Visual Effects | Atsuki Sato | CGI Director |
| Crew | Katsuro Onoue | Other |
| Visual Effects | Tomoo Haraguchi | Modeling |
| Visual Effects | Mahiro Maeda | Creature Design |
| Visual Effects | Shinji Higuchi | Creature Design |
| Lighting | Sosuke Yoshikado | Gaffer |
| Sound | Yasuo Hashimoto | Sound |
| Directing | Hideaki Murakami | Assistant Director |
| Directing | Koji Yamaguchi | Assistant Director |
| Crew | Yûichi Kikuchi | Special Effects Assistant |
| Sound | Shin'ichi Itô | Sound Effects |
