Dr. Hess Green becomes cursed by a mysterious ancient African artifact and is overwhelmed with a newfound thirst for blood. Soon after his transformation he enters into a dangerous romance with Ganja Hightower that questions the very nature of love, addiction, sex, and status.
| Art | Kay Lee | Production Design |
| Art | Philippa Culpepper | Set Decoration |
| Production | Kerry Mondragon | Associate Producer |
| Production | Numa Perrier | Co-Producer |
| Production | Kim Taylor-Coleman | Casting |
| Writing | Spike Lee | Screenplay |
| Production | Spike Lee | Producer |
| Costume & Make-Up | Ruth E. Carter | Costume Design |
| Editing | Randy Wilkins | Editor |
| Production | Jason Sokoloff | Co-Producer |
| Directing | Spike Lee | Director |
| Sound | Bruce Hornsby | Original Music Composer |
| Camera | Henry Adebonojo | Camera Operator |
| Camera | Daniel Patterson | Director of Photography |
| Writing | Bill Gunn | Writer |
| Production | Mark Cuban | Associate Producer |