Pushed to the breaking-up point after their latest 'why can't you do this one little thing for me?' argument, Brooke calls it quits with her boyfriend Gary. What follows is a hilarious series of remedies, war tactics, overtures and undermining tricks – all encouraged by the former couple's friends and confidantes …and the occasional total stranger! When neither ex is willing to move out of their shared apartment, the only solution is to continue living as hostile roommates until one of them reaches breaking point.
| Directing | Peyton Reed | Director |
| Editing | Dan Lebental | Editor |
| Editing | David Rosenbloom | Editor |
| Camera | Eric Alan Edwards | Director of Photography |
| Production | Stuart M. Besser | Executive Producer |
| Production | Peter Billingsley | Executive Producer |
| Production | Scott Stuber | Producer |
| Production | Vince Vaughn | Producer |
| Writing | Jeremy Garelick | Screenplay |
| Writing | Jay Lavender | Screenplay |
| Writing | Vince Vaughn | Story |
| Writing | Jeremy Garelick | Story |
| Writing | Jay Lavender | Story |
| Production | Jay Lavender | Co-Producer |
| Production | Jeremy Garelick | Co-Producer |
| Production | Victoria Vaughn | Associate Producer |
| Production | John Isbell | Associate Producer |
| Production | Juel Bestrop | Casting |
| Production | Jeanne McCarthy | Casting |
| Sound | John O'Brien | Music Supervisor |
| Costume & Make-Up | Carol Oditz | Costume Design |
| Art | Andrew Laws | Production Design |
| Production | Stuart M. Besser | Unit Production Manager |
| Directing | Todd Amateau | First Assistant Director |
| Directing | Nina Jack | Second Assistant Director |
| Production | Mitchell E. Dauterive | Production Supervisor |
| Crew | Joe Bucaro III | Stunt Coordinator |
| Art | Daniel B. Clancy | Set Decoration |
| Art | Scott Troha | Leadman |
| Art | David Sandefur | Art Direction |
| Art | Marco Rubeo | Assistant Art Director |
| Art | Brian Cho | Art Department Coordinator |
| Art | Stephanie Gilliam | Set Designer |
| Art | Paul Meylink | Storyboard Artist |
| Production | Stacy Laiderman | Art Department Production Assistant |
| Camera | Peter Rosenfeld | "A" Camera Operator |
| Camera | Peter Rosenfeld | Steadicam Operator |
| Camera | Peter Kuttner | First Assistant "A" Camera |
| Camera | Colin Slaby | Second Assistant "A" Camera |
| Camera | Jody Williams | "B" Camera Operator |
| Camera | George Kohut | "B" Camera Operator |
| Camera | Paul DeMarte | First Assistant "B" Camera |
| Camera | Greg Jackson | Second Assistant "B" Camera |
| Camera | Jody Williams | Second Unit Director of Photography |
| Camera | Joe Carpita | Camera Loader |
| Camera | Melissa Moseley | Still Photographer |
| Directing | Sheila Waldron | Script Supervisor |
| Sound | John Pritchett | Production Sound Mixer |
| Sound | David M. Roberts | Boom Operator |
| Crew | Lisa Gillespie | Cableman |
| Lighting | Dick Oakes | Gaffer |
| Lighting | Robert Swander | Best Boy Electric |
| Lighting | Chris Mulsoff | Rigging Gaffer |
| Camera | Art Bartels | Key Grip |
| Camera | Don Miller | Best Boy Grip |
| Camera | John Hudecek | Dolly Grip |
| Camera | Fred Folmer | Dolly Grip |
| Lighting | James F. Roorda | Key Rigging Grip |
| Art | William D'Ambra | Property Master |
| Art | David J. Chamerski | Assistant Property Master |
| Production | Al Nolan-Cohn | Location Manager |
| Production | Martha Lafage | Assistant Location Manager |
| Production | Patrick Muldoon | Assistant Location Manager |
| Art | Maria C. Roxas | Location Scout |
| Production | Elicia Zimmerman | Location Coordinator |
| Directing | Anthony J. Nahar | Second Second Assistant Director |
| Costume & Make-Up | Thomas J. Glynn | On Set Dresser |
| Crew | John D. Milinac | Special Effects Coordinator |
| Costume & Make-Up | Claire Hallworth | Costume Designer |
| Costume & Make-Up | Nina Hallworth | Costume Designer |
| Costume & Make-Up | Terry Anderson | Assistant Costume Designer |
| Costume & Make-Up | Ellen Ryba | Assistant Costume Designer |
| Costume & Make-Up | Joyce Kogut | Costume Supervisor |
| Costume & Make-Up | Annie Laoparadonchai | Costumer |
| Costume & Make-Up | Gina Marie Ome | Key Costumer |
| Costume & Make-Up | Jacqueline S. Beatka | Set Costumer |
| Costume & Make-Up | Nancy Cavallaro | Set Costumer |
| Costume & Make-Up | Alyssa Kim | Costumer |
| Costume & Make-Up | Jane Blank | Seamstress |
| Costume & Make-Up | Suzi Ostos | Makeup Department Head |
| Costume & Make-Up | Angela Levin | Makeup Artist |
| Costume & Make-Up | Dominic Mango | Hair Department Head |
| Costume & Make-Up | Chris McMillan | Hairstylist |
| Costume & Make-Up | Tony Mirante | Assistant Hairstylist |
| Production | Seth Yanklewitz | Casting Associate |
| Production | Jaime Harlan | Casting Assistant |
| Production | Mickie Paskal | Local Casting |
| Production | Jennifer Rudnicke | Local Casting |
| Production | Joseph Hicks | Extras Casting |
| Production | Tracy Dixon | Extras Casting |
| Production | Ruth Goff | Extras Casting |
| Production | Jonathan Kinnas | Extras Casting |
| Production | Andrew Blau | Production Coordinator |
| Production | Barry Barclay | Production Coordinator |
| Production | Paula Stier | Production Secretary |
| Production | Lori Scowley | Production Accountant |
| Crew | Sean T. Stratton | Post Production Supervisor |
| Editing | Gregory Plotkin | First Assistant Editor |
| Editing | Sandra Torres Granovsky | First Assistant Editor |
| Editing | Richmond Riedel | Assistant Editor |
| Art | Bruce DiValerio | Construction Coordinator |
| Crew | Thaddeus E. Larkowski | Transportation Coordinator |
| Crew | Michael P. Deal | Transportation Captain |
| Crew | Darnell Jones | Transportation Co-Captain |
| Sound | Cameron Frankley | Sound Supervisor |
| Sound | Cameron Frankley | Sound Designer |
| Sound | Jon Michaels | First Assistant Sound Editor |
| Sound | Kimberly Harris | Supervising ADR Editor |
| Sound | Linda Folk | ADR Editor |
| Sound | Ulrika Akander | Supervising Dialogue Editor |
| Sound | Teri E. Dorman | Dialogue Editor |
| Sound | David Williams | Dialogue Editor |
| Sound | David V. Butler | Dialogue Editor |
| Sound | Jason W. Jennings | Sound Effects Editor |
| Sound | Randy Kelley | Sound Effects Editor |
| Sound | Ai-Ling Lee | Sound Effects Editor |
| Sound | Scott Curtis | Foley Editor |
| Sound | Christopher Flick | Foley Editor |
| Sound | Kevin Warendorp | Assistant Sound Editor |
| Sound | Doc Kane | ADR Mixer |
| Sound | Thomas J. O'Connell | ADR Mixer |
| Sound | Jeanette Browning | ADR Recordist |
| Sound | Rick Canelli | ADR Recordist |
| Sound | David Betancourt | Foley Mixer |
| Sound | Alicia Stevenson | Foley Artist |
| Sound | Dawn Fintor | Foley Artist |
| Production | Barbara Harris | ADR Voice Casting |
| Sound | Steve Pederson | Sound Re-Recording Mixer |
| Sound | Brad Sherman | Sound Re-Recording Mixer |
| Sound | Jonathan Karp | Music Editor |
| Sound | Steve Bartek | Orchestrator |
| Sound | Steve Bartek | Conductor |
| Editing | Gary Burritt | Negative Cutter |
| Sound | Jon Brion | Original Music Composer |
| Costume & Make-Up | Clare Hallworth | Costume Design |
| Costume & Make-Up | Chelo Ontiveros | Key Makeup Artist |
| Crew | Steve Hull | Carpenter |
| Costume & Make-Up | Lisa Jelic | Makeup Artist |
| Art | Veloz Gomez | Set Dresser |
| Sound | Jon Michaels | Assistant Sound Editor |
| Sound | Dan Guachione | Boom Operator |
| Crew | Virginia Landis Albertson | Post Production Supervisor |
| Production | Mike Doto | Production Manager |
| Crew | Brigitte Bourque | Compositor |
| Camera | Steven R. Wojcik | Additional Camera |
| Camera | David Norris | Aerial Director of Photography |
| Camera | Louisa McHugh | Camera Intern |
| Camera | E.J. Huntemann | Grip |
| Lighting | Noah Banks | Lighting Technician |
| Lighting | Jaime Dawkins | Rigging Grip |
| Art | Terry Baughman | Construction Foreman |
| Editing | Jim Passon | Color Timer |
| Editing | Olivia Giachino | Editorial Production Assistant |
| Sound | Jackie Gleason | Musician |
| Crew | Michael R. Cairo | Driver |
| Crew | John J. Slove Jr. | Propmaker |
| Art | Kyle Holden | Props |
| Crew | Marijan 'Mario' Zoric | Chef |
| Crew | Assata Amoaku | Craft Service |
| Production | Gail Rose | Post Production Accountant |
| Crew | Nathaniel E. Bell | Set Production Assistant |
| Sound | Kirk Francis | Sound Mixer |
| Sound | Eric Flickinger | Sound Recordist |
| Crew | Joe Andaloro | Stand In |
| Crew | John M. Pisani | Unit Publicist |
| Visual Effects | Thomas J. Smith | Visual Effects Supervisor |
| Visual Effects | Heather Elisa Hill | Visual Effects Coordinator |
| Costume & Make-Up | Erika Walthall | Costume Assistant |
| Costume & Make-Up | Patrick Caulfield | Key Set Costumer |
| Crew | Michael T. Brady | Stunts |
| Directing | Cara Giallanza | Assistant Director |
| Camera | George Kohut | Camera Operator |
| Lighting | Chad Catuara | Electrician |
| Art | David E. Scott | Graphic Designer |
| Art | Matt Reitsma | Textile Artist |
| Crew | Frank Battaglia | Special Effects Technician |
| Crew | Kym Washington Longino | Stunt Double |
| Production | Alex Cohn | Location Manager |
| Camera | Joe Gajewski | Additional Grip |
| Sound | Jay Duerr | Music Editor |
| Camera | Eric Wheeler | Assistant Camera |
| Editing | Stacey Frederick | Assistant Editor |
| Editing | Donnie Creighton | Digital Intermediate Assistant |
| Editing | Mike Kennedy | Digital Intermediate Producer |
| Production | Frank Cuomo | Post Production Coordinator |
| Production | Nick Rafferty | Location Assistant |
| Production | Abby Lorts | Location Production Assistant |
| Production | Cliff Zimowski | Additional Production Assistant |
| Crew | Michael Franck | Aerial Coordinator |
| Production | Jeremy Beiermann | Assistant Production Coordinator |
| Visual Effects | Eric Pender | CG Artist |
| Crew | Ina Haybaeck-Rogers | Choreographer |
| Production | Lindsay Heller | Extras Casting Assistant |
| Production | Crista Birgy | First Assistant Accountant |
| Production | Donald Fly | General Manager |
| Production | Timber Kislan | Payroll Accountant |
| Production | Olivier Agostini | Production Assistant |
| Production | Jennifer Webb | Travel Coordinator |
| Crew | Michelle Johnston | Choreographer |
| Crew | Michelle Sleger | Stand In |
| Crew | Linda Cohn | Thanks |
| Crew | Teresa Lang | Thanks |
| Crew | Troy Gilbert | Stunts |
| Crew | Linda Perlin | Stunts |
| Crew | Lance Gilbert | Stunts |
