The story of how a mysterious suitcase brings together, and changes, the lives of a divorced dad, an unhappy housewife, two hitmen, a pair of street thugs, two love struck teens, two FBI men and a psychedelic toad. Based on Pulitzer Prize-winning humorist Dave Barry's best-selling first novel, "Big Trouble."
| Camera | Greg Gardiner | Director of Photography |
| Writing | Robert Ramsey | Screenplay |
| Editing | Steven Weisberg | Editor |
| Directing | Barry Sonnenfeld | Director |
| Production | Barry Sonnenfeld | Producer |
| Sound | James Newton Howard | Original Music Composer |
| Production | Donald Dowd | Art Department Production Assistant |
| Sound | Arturo Sandoval | Musician |
| Writing | Matthew Stone | Screenplay |
| Writing | Dave Barry | Novel |
| Production | Barry Josephson | Producer |
| Production | Tom Jacobson | Producer |
| Production | Graham Place | Co-Producer |
| Production | Jim Wedaa | Executive Producer |
| Art | Garreth Stover | Production Design |
| Costume & Make-Up | Mary E. Vogt | Costume Design |
| Sound | Dawn Solér | Music Supervisor |
| Production | Ronna Kress | Casting |
| Production | Graham Place | Unit Production Manager |
| Directing | Chris Soldo | First Assistant Director |
| Directing | Greg Hale | Second Assistant Director |
| Production | Sara E. White | Production Supervisor |
| Production | Chris Soldo | Associate Producer |
| Art | J. Mark Harrington | Art Direction |
| Art | Cindy Carr | Set Decoration |
| Sound | Peter F. Kurland | Sound Mixer |
| Sound | Steve Bowerman | Sound Mixer |
| Costume & Make-Up | Eileen McCahill | Costume Supervisor |
| Costume & Make-Up | Katherine James | Key Makeup Artist |
| Costume & Make-Up | Katherine James | Makeup Artist |
| Costume & Make-Up | Jay Cannistraci | Assistant Makeup Artist |
| Costume & Make-Up | Shane Paish | Makeup Artist |
| Directing | Diane Calhoun | Second Second Assistant Director |
| Art | Richard Fojo | Set Designer |
| Crew | Paul A. Levin | Post Production Supervisor |
| Sound | Skip Lievsay | Supervising Sound Editor |
| Sound | Sean Garnhart | Supervising Sound Editor |
| Sound | Bobby Mackston | Supervising Dialogue Editor |
| Sound | Lewis Goldstein | Sound Effects Editor |
| Sound | Lee Dichter | Sound Re-Recording Mixer |
| Sound | Skip Lievsay | Sound Re-Recording Mixer |
| Sound | Sean Garnhart | Sound Re-Recording Mixer |
| Directing | Artie Malesci | Second Unit Director |
| Costume & Make-Up | Darren Levy | Makeup Artist |
| Visual Effects | Stephen Rosenbaum | Visual Effects Supervisor |
| Visual Effects | Dana Friedman | Visual Effects Producer |
| Crew | Glenn R. Wilder | Stunts |
| Crew | Jill Brown | Stunt Driver |
| Crew | Jennifer Badger | Stunts |
| Crew | Chick Bernhard | Stunts |
