Seven years after the defeat of the spiral king, Simon and the Dai-Gurren brigade must set out to the vastness of space to defeat a new threat and save the universe.
| Directing | Hiroyuki Imaishi | Director |
| Art | Yuka Hirama | Art Direction |
| Sound | Toru Nakano | Sound Director |
| Sound | Taku Iwasaki | Music |
| Camera | Toyonori Yamada | Director of Photography |
| Visual Effects | Harumi Takahoshi | Color Designer |
| Writing | Kazuki Nakashima | Writer |
| Crew | Kazuki Nakashima | Creator |
| Directing | Masahiko Otsuka | Assistant Director |
| Production | Yasuhiro Takeda | Producer |
| Production | Hiromi Wakabayashi | Co-Producer |
| Art | Hiroyuki Imaishi | Storyboard Artist |
| Visual Effects | Atsushi Nishigori | Animation Director |
| Visual Effects | Hiroyuki Imaishi | Animation Director |
| Visual Effects | Yusuke Yoshigaki | Key Animation |
| Visual Effects | Yuka Shibata | Key Animation |
| Visual Effects | Yoshihiko Umakoshi | Key Animation |
| Visual Effects | Yoh Yoshinari | Key Animation |
| Visual Effects | Takashi Mukouda | Key Animation |
| Visual Effects | Tadashi Hiramatsu | Key Animation |
| Visual Effects | Sushio | Key Animation |
| Visual Effects | Shoko Nishigaki | Key Animation |
| Visual Effects | Shouko Nakamura | Key Animation |
| Visual Effects | Shingo Natsume | Key Animation |
| Visual Effects | Shingo Abe | Key Animation |
| Visual Effects | Satoshi Yamaguchi | Key Animation |
| Visual Effects | Ryoji Masuyama | Key Animation |
| Visual Effects | Nozomi Goto | Key Animation |
| Visual Effects | Kouichi Motomura | Key Animation |
| Visual Effects | Kenichi Yoshida | Key Animation |
| Visual Effects | Keisuke Watanabe | Key Animation |
| Visual Effects | Katsuzo Hirata | Key Animation |
| Visual Effects | Itsuki Imazaki | Key Animation |
| Visual Effects | Ikuo Kuwana | Key Animation |
| Visual Effects | Hitomi Hasegawa | Key Animation |
| Visual Effects | Hiroyuki Imaishi | Key Animation |
| Visual Effects | Hiroyasu Oda | Key Animation |
| Visual Effects | Hironori Tanaka | Key Animation |
| Visual Effects | Hiroki Mutaguchi | Key Animation |
| Visual Effects | Hirokazu Kojima | Key Animation |
| Visual Effects | Fumiaki Kouta | Key Animation |
| Visual Effects | Chikashi Kubota | Key Animation |
| Visual Effects | Atsushi Nishigori | Key Animation |
| Visual Effects | Akira Amemiya | Key Animation |
| Visual Effects | Akemi Hayashi | Key Animation |
| Directing | Yasuhiro Geshi | Director |
| Directing | Hiroshi Ikehata | Director |
| Directing | Ryuichi Kimura | Director |
| Directing | Ayumu Kotake | Director |
| Directing | Katsuichi Nakayama | Director |
| Directing | Shouji Saeki | Director |
| Directing | Toshiya Shinohara | Director |
| Directing | Yutaka Uemura | Director |
| Directing | Yorifusa Yamaguchi | Director |
| Directing | Tooru Yoshida | Director |
| Directing | Masahiko Otsuka | Director |
| Writing | Kazuki Nakashima | Original Film Writer |
| Writing | Kazuki Nakashima | Screenplay |
| Writing | Kurasumi Sunayama | Screenplay |
| Writing | Hiroshi Yamaguchi | Screenplay |
