The plot of Marine Express can be described in two parts. The first part focuses on the people boarding the train and the problems they encounter on it. The second part takes place after the train has stopped at its half-way point, an island that used to be home to an ancient civilization millennia ago and has its fair share of secrets.
| Directing | Satoshi Dezaki | Director |
| Sound | Yuji Ohno | Original Music Composer |
| Art | Mitsunari Makino | Art Direction |
| Editing | Hiroshi Shinohara | Color Timer |
| Production | Akira Yoshikawa | Producer |
| Writing | Osamu Tezuka | Story |
| Production | Michitoshi Shimakata | Executive Producer |
| Production | Tadahiko Tsuzuki | Producer |
| Visual Effects | Shigetaka Kiyoyama | Animation Director |
| Visual Effects | Osamu Tezuka | Character Designer |
| Art | Nao Sakaguchi | Settings |
| Editing | Kazuo Inoue | Editor |
