The nefarious Dr. Fu Manchu searches for the keys to the tomb of Genghis Khan, in order to fulfill a prophecy that will enable him to conquer the world. His nemesi, Dr. Nayland Smith and his associates fight to keep the evil doctor from getting his hands on the keys. In 1943 the serial was edited together into a feature movie also called Drums of Fu Manchu.
| Directing | John English | Director |
| Directing | William Witney | Director |
| Writing | Franklin Adreon | Screenplay |
| Writing | Morgan Cox | Screenplay |
| Writing | Ronald Davidson | Screenplay |
| Writing | Norman S. Hall | Screenplay |
| Writing | Sax Rohmer | Novel |
| Writing | Barney A. Sarecky | Screenplay |
| Writing | Sol Shor | Screenplay |
| Production | Hiram S. Brown Jr. | Producer |
| Sound | Paul Sawtell | Original Music Composer |
| Camera | William Nobles | Director of Photography |
| Art | John Victor Mackay | Co-Art Director |
| Art | Morris Braun | Set Decoration |
| Costume & Make-Up | Bob Mark | Makeup Artist |
| Editing | Edward Todd | Editor |
| Sound | Cy Feuer | Original Music Composer |
| Editing | William P. Thompson | Editor |
