Dr. Frankenstein and his monster both turn out to be alive, not killed as previously believed. Dr. Frankenstein wants to get out of the evil experiment business, but when a mad scientist, Dr. Pretorius, kidnaps his wife, Dr. Frankenstein agrees to help him create a new creature.
| Directing | James Whale | Director |
| Editing | Ted J. Kent | Editor |
| Sound | Franz Waxman | Original Music Composer |
| Production | Carl Laemmle Jr. | Producer |
| Camera | John J. Mescall | Director of Photography |
| Costume & Make-Up | Vera West | Costume Design |
| Art | Charles D. Hall | Art Direction |
| Costume & Make-Up | Jack Pierce | Makeup Artist |
| Writing | William Hurlbut | Adaptation |
| Writing | John L. Balderston | Adaptation |
| Editing | Maurice Pivar | Supervising Film Editor |
| Writing | William Hurlbut | Screenplay |
| Crew | Peter Shaw | Stand In |
| Camera | Fred Stoll | Grip |
| Crew | John P. Fulton | Special Effects |
| Sound | C. Bakaleinikoff | Orchestrator |
| Writing | Robert Florey | Story |
| Costume & Make-Up | Irma Kusely | Hairstylist |
| Costume & Make-Up | Otto Lederer | Assistant Makeup Artist |
| Sound | Gilbert Kurland | Sound Supervisor |
| Sound | William Hedgcock | Sound Engineer |
| Writing | Josef Berne | Adaptation |
| Writing | Lawrence G. Blochman | Adaptation |
| Writing | Philip MacDonald | Adaptation |
| Crew | Tom Reed | Additional Writing |
| Writing | R.C. Sherriff | Adaptation |
| Writing | Edmund Pearson | Screenplay |
| Writing | Morton Covan | Adaptation |
| Costume & Make-Up | Irma Kusely | Hair Setup |
| Costume & Make-Up | Otto Lederer | Makeup Trainee |
| Directing | Fred Frank | Assistant Director |
| Directing | Harry Mancke | Assistant Director |
| Directing | Joseph A. McDonough | Assistant Director |
| Crew | David S. Horsley | Special Effects Assistant |
| Crew | Ken Strickfaden | Special Effects Technician |
| Visual Effects | John P. Fulton | Visual Effects Camera |
| Visual Effects | Cleo E. Baker | Visual Effects |
| Visual Effects | Russell Lawson | Visual Effects |
| Visual Effects | Jack Cosgrove | Visual Effects |
| Visual Effects | David S. Horsley | Visual Effects |
| Camera | William Dodds | Assistant Camera |
| Camera | Alan Jones | Camera Operator |
| Sound | Larry Aicholtz | Scoring Mixer |
| Sound | Abe Meyer | Music Coordinator |
| Sound | Clifford Vaughan | Orchestrator |
| Sound | Oliver Wallace | Musician |
| Writing | Flo Brummel | Script Consultant |
| Crew | George DeNormand | Stand In |
| Crew | Monte Montague | Stand In |
| Sound | Edwin Wetzel | Sound Effects Editor |
| Writing | Mary Shelley | Original Story |
