Bob Casale
- Birthday: 1952-07-14
- Deathday: 2014-02-17
- Place of birth: Kent, Ohio, USA
- Also know as: Bob 2
Robert Edward Casale, also known as Bob 2, was a member of the new wave band Devo, co-founded by his brother, Gerald Casale. He performed rhythm guitar, keyboards, and backing vocals for the band. He later became a composer for movie soundtracks. He died of heart failure in 2014 at the age of 61.
