Mangosuthu Buthelezi
- Birthday: 1928-08-27
- Deathday: 2023-09-09
- Place of birth: Mahlabathini, Colony of Natal, South Africa
- Also know as: Chief Mangosuthu Buthelezi
Prince Mangosuthu Gatsha Buthelezi was a South African politician and Zulu prince who served as the traditional prime minister to the Zulu royal family from 1954 until his death in 2023. He was appointed to this post by King Bhekuzulu, the son of King Solomon kaDinuzulu.
