Charlie Duke
- Birthday: 1935-10-03
- Place of birth: Charlotte, North Carolina, USA
- Also know as: Charles Duke
Charles Moss Duke Jr. (born October 3, 1935) is an American former astronaut, United States Air Force (USAF) officer and test pilot. As Lunar Module pilot of Apollo 16 in 1972, he became the 10th and youngest person to walk on the Moon, at age 36 years and 201 days.
