The mega-corporate Daedalus Group is under attack by a small group of activists known as the Ghost of Icarus. While taking care of some of the victims of the bombing, Black Jack encounters Dr. Kiriko, also known as Death Incarnate, who just like him, asks his patients huge sums of money but instead of saving them, he offers them a painless death. When the activist group requests both doctors’ collaboration, Black Jack finds himself caught in a spiral of life, death and treason while trying to save his patients' lives and avoid the breaking of a biological war that could destroy humanity.
| Writing | Katsuhiko Chiba | Screenplay |
| Writing | Osamu Tezuka | Original Story |
| Production | Tomoyuki Saito | Producer |
| Production | Minoru Kubota | Producer |
| Writing | Hirotoshi Kobayashi | Screenplay |
| Production | Michihiko Suwa | Producer |
| Production | Sumio Udagawa | Producer |
| Directing | Satoshi Kuwabara | Director |
| Directing | Makoto Tezuka | Director |
| Editing | Seiji Morita | Editor |
| Art | Mieko Ichihara | Art Direction |
| Crew | Osamu Tezuka | Creator |
| Camera | Keisuke Nakamura | Director of Photography |
| Visual Effects | Juuji Mizumura | Key Animation |
| Visual Effects | Tamotsu Ogawa | Key Animation |
| Visual Effects | Toshiharu Sugie | Key Animation |
| Visual Effects | Jouji Yanase | Key Animation |
| Visual Effects | Manabu Oohashi | Key Animation |
| Visual Effects | Naoki Takahashi | Key Animation |
| Visual Effects | Hiroyo Izumi | Key Animation |
| Visual Effects | Aya Sato | Key Animation |
| Visual Effects | Daiki Handa | Key Animation |
| Visual Effects | Mizuka Takahashi | Key Animation |
| Visual Effects | Toshiki Yoshida | Key Animation |
| Visual Effects | Yoshie Anzai | Key Animation |
| Visual Effects | Yukie Harada | Key Animation |
| Visual Effects | Yukie Tsukamoto | Key Animation |
| Visual Effects | Hua Wei | Key Animation |
| Visual Effects | Daisuke Ito | Key Animation |
| Visual Effects | Michio Hasegawa | Key Animation |
| Visual Effects | Motohiko Kurihara | Key Animation |
| Visual Effects | Takanori Suzuki | Key Animation |
| Visual Effects | Kim In-soo | Key Animation |
| Visual Effects | Shuji Tanaka | Key Animation |
| Visual Effects | Misato Ootani | Key Animation |
| Visual Effects | Keisuke Gotou | Key Animation |
| Visual Effects | Masayuki Yoshida | Key Animation |
| Visual Effects | Kazuchika Kise | Key Animation |
| Visual Effects | Yoshinori Tanabe | Key Animation |
| Visual Effects | Shinya Nogami | Key Animation |
| Visual Effects | Kae Anzai | Key Animation |
| Visual Effects | Tomoko Sato | Key Animation |
| Visual Effects | Nobuyasu Murakami | Key Animation |
| Visual Effects | Keizo Shimizu | Key Animation |
| Visual Effects | Kouji Kawaguchi | Key Animation |
| Visual Effects | Miho Aoki | Key Animation |
| Visual Effects | Tomokatsu Nagasaku | Key Animation |
| Visual Effects | Kyouko Takeuchi | Key Animation |
| Visual Effects | Nobuko Shinohara | Key Animation |
| Visual Effects | Nana Yonemoto | Key Animation |
| Visual Effects | Hideyuki Hakuya | Key Animation |
| Visual Effects | Hiroyuki Okuno | Key Animation |
| Visual Effects | Kazunari Kume | Key Animation |
| Visual Effects | Kayoko Suzuki | Key Animation |
| Visual Effects | Shinya Takahashi | Key Animation |
| Visual Effects | Nobuko Sugino | Key Animation |
| Visual Effects | Michinosuke Nakamura | Key Animation |
| Visual Effects | Kazunori Aoki | Key Animation |
| Visual Effects | Kumiko Takayanagi | Key Animation |
| Visual Effects | Miyuki Katayama | Key Animation |
| Visual Effects | Shinji Seya | Key Animation |
| Visual Effects | Hiroshi Uchida | Key Animation |
| Sound | Isao Tomita | Original Music Composer |
