Six years after the events of The X-Files series finale, former FBI agent Doctor Dana Scully is now a staff physician at Our Lady of Sorrows, a Catholic hospital, and treating a boy named Christian who has Sandhoff disease, a terminal brain condition. FBI agent Drummy arrives to ask Scully’s help in locating Fox Mulder, the fugitive former head of the X-Files division, and says they will call off its manhunt for him if he will help investigate the disappearances of several women, including young FBI agent Monica Banan. Mulder and Scully are called back to duty by the FBI when a former priest claims to be receiving psychic visions pertaining to a kidnapped agent.
| Writing | Chris Carter | Screenplay |
| Directing | Chris Carter | Director |
| Writing | Frank Spotnitz | Screenplay |
| Writing | Jenny Seinen | Storyboard |
| Crew | David Gauthier | Special Effects Coordinator |
| Crew | Michel Barrière | Compositors |
| Visual Effects | Rod Park | Visual Effects Producer |
| Production | Dan Rucinski | Production Supervisor |
| Visual Effects | Trent Smith | Visual Effects Producer |
| Crew | James Bamford | Stunts |
| Crew | Tony Morelli | Stunts Coordinator |
| Production | Chris Carter | Producer |
| Crew | Julio Pallares | Makeup Effects |
| Art | David Hadaway | Set Designer |
| Costume & Make-Up | Scott Holburn | Set Dressing Artist |
| Visual Effects | Anouk Deveault-Moreau | Visual Effects Supervisor |
| Visual Effects | Jack Noriaki Matsumoto | CG Painter |
| Visual Effects | Dmitry Vinnik | CG Painter |
| Camera | Mitch Bax | Camera Intern |
| Camera | Bill Roe | Director of Photography |
| Costume & Make-Up | Geoff Coulter | Set Dressing Artist |
| Sound | David Giammarco | Sound Re-Recording Mixer |
| Production | Anne Tremblay | Administration |
| Crew | Mike Dobbin | Stunts |
| Crew | Jeff Sanca | Stunts |
| Costume & Make-Up | Gitte Axen | Makeup Artist |
| Production | Brent O'Connor | Executive Producer |
| Art | Cheryl Marion | Assistant Art Director |
| Sound | Alicia Stevenson | Foley |
| Visual Effects | Steve Au | CG Painter |
| Visual Effects | Glenn Curry | CG Painter |
| Crew | Linda Drake | Visual Effects Editor |
| Visual Effects | Junji Hirano | CG Painter |
| Visual Effects | Andrew Lema | CG Painter |
| Visual Effects | John C. Wash | Visual Effects Supervisor |
| Crew | Dean Hart | Stunts |
| Production | Heike Brandstatter | Casting |
| Sound | David Grimaldi | Sound Effects Editor |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Visual Effects | Mat Beck | Visual Effects Supervisor |
| Crew | Andrew Edwards | Compositors |
| Crew | Bill Edwards | Stunts |
| Camera | Matt Almas | Grip |
| Sound | Mark Snow | Original Music Composer |
| Crew | Christopher Mark Pinhey | Makeup Effects |
| Crew | E. J. Foerster | Second Unit |
| Crew | David Alexander | CG Supervisor |
| Crew | Charles Collyer | Compositors |
| Visual Effects | Thomas F. Ford IV | Visual Effects Producer |
| Crew | Mark Goldberg | Compositors |
| Art | Shirley Inget | Set Decoration |
| Costume & Make-Up | Raul Casillas | Set Dressing Artist |
| Sound | Randall Guth | First Assistant Sound Editor |
| Crew | Don Greenberg | Compositors |
| Crew | Richard Martin | Compositors |
| Crew | Steve J. McLeod | Compositors |
| Visual Effects | Tena Montoya | Visual Effects Producer |
| Crew | Brian Sales | Compositors |
| Crew | Chris Atkinson | Stunts |
| Crew | Duane Dickinson | Stunts |
| Crew | Corbin Fox | Stunts |
| Crew | Chris Webb | Stunts |
| Costume & Make-Up | Victoria Down | Makeup Department Head |
| Costume & Make-Up | Sandy Monesmith | Hairstylist |
| Production | Simon Abbott | Production Manager |
| Production | Wayne Bennett | Production Manager |
| Costume & Make-Up | Jared Brown | Set Dressing Artist |
| Art | Mike Rennison | Construction Coordinator |
| Crew | Jason Dunn | Compositors |
| Lighting | Ryan Bailey | Gaffer |
| Art | Mark S. Freeborn | Production Design |
| Art | Tony Wohlgemuth | Art Direction |
| Costume & Make-Up | Leonardo Lara | Set Dressing Artist |
| Art | Paul Rinaldi | Construction Foreman |
| Sound | Warren Hendriks | Sound Effects Editor |
| Visual Effects | Brenda Ilic | Visual Effects Producer |
| Crew | Vinay Mehta | Compositors |
| Crew | Mike Spring | Compositors |
| Crew | Donald Tse | Compositors |
| Crew | Natasha Vasiluk | Stunts |
| Production | Mindy Marin | Casting |
| Crew | Bill Terezakis | Makeup Effects |
| Crew | Maureen Terezakis | Makeup Effects |
| Visual Effects | Joni Jacobson | Visual Effects Producer |
| Crew | Mike Mitchell | Stunt Coordinator |
| Crew | David McKimmie | Post-Production Manager |
| Costume & Make-Up | Mark Prior | Set Dressing Artist |
| Sound | Charleen Richards-Steeves | ADR & Dubbing |
| Crew | William Unrau | Cableman |
| Visual Effects | Randal Shore | Visual Effects Producer |
| Crew | Kimberly Chiang | Stunts |
| Production | Coreen Mayrs | Casting |
| Sound | David Betancourt | Foley |
| Crew | Rodrigo Armendariz | Compositors |
| Crew | Matthias Lowry | Compositors |
| Crew | Pierre Raymond | Executive Visual Effects Producer |
| Visual Effects | Ian Wilson | CG Painter |
| Crew | Guy Bews | Stunts |
| Crew | Marshall Virtue | Stunts |
| Crew | George Collins | Video Assist Operator |
| Editing | Richard A. Harris | Editor |
| Costume & Make-Up | Lisa Tomczeszyn | Costume Design |
| Production | Brent O'Connor | Unit Production Manager |
| Sound | David Lucarelli | ADR & Dubbing |
| Crew | Wayne A. Shepherd | Compositors |
| Crew | Jennifer Mylrea | Stunts |
| Production | Frank Spotnitz | Producer |
| Crew | Paul Rabwin | Post Production Supervisor |
| Sound | Chuck Michael | Sound Designer |
| Sound | Erin Michael Rettig | Sound Engineer |
| Visual Effects | Eugene Paluso | CG Painter |
| Visual Effects | Andrea Shear | CG Painter |
| Crew | Christina Spring | Compositors |
| Crew | Marty Taylor | Compositors |
| Crew | Melissa R. Stubbs | Stunts |
| Sound | Martin Lacroix | Boom Operator |
| Crew | Ryan Epp | Compositors |
| Visual Effects | Daniel Leduc | Visual Effects Producer |
| Crew | Brian Petras | Compositors |
| Crew | Patrick Thompson | Compositors |
| Crew | Dave Williams | Compositors |
| Crew | Dave Lane | Stunts |
| Art | Sabine Schoppel | Art Department Coordinator |
| Visual Effects | Graham Houston | CG Painter |
| Crew | Todd Scott | Stunts |
| Sound | Matthew Harrison | Foley Editor |
| Art | Marta McLaughlin | Assistant Property Master |
| Camera | Cory Budney | First Assistant Camera |
| Sound | Tim Gomillion | Sound Recordist |
| Sound | Scott Curtis | Foley Editor |
| Sound | Dennis Rogers | Sound Recordist |
| Sound | Gloria D'Alessandro | Dialogue Editor |
| Sound | Eric A. Larsen | Assistant Sound Editor |
| Visual Effects | Bryce Brecheisen | Visual Effects Coordinator |
| Sound | Galen Goodpaster | Assistant Sound Editor |
| Sound | Michael T. Williamson | Sound Mixer |
| Art | Eric Partridge | Assistant Property Master |
| Sound | Mildred Iatrou | ADR Editor |
| Art | Brad McMurray | Set Decorating Coordinator |
| Camera | John S. Bartley | Second Unit Director of Photography |
| Directing | Portia Tickell | Script Supervisor |
| Sound | Smokey Cloud | Assistant Sound Editor |
| Art | Wayne McLaughlin | Property Master |
| Visual Effects | Shane Strickman | Visual Effects Coordinator |
| Production | Mark Sweatman | Production Assistant |
| Crew | Charles Andre | Stunts |
