A massive underwater volcano erupts and puts a group of investigative scientists in danger. They are rescued by an atomic super submarine named The Alpha under the command of Captain McKenzie. The group is quickly taken to a vast underwater city known as Latitude Zero, a fantastic, Atlantean type utopia, a world beneath the ocean with its own sun. It is soon discovered that Captain McKenzie is at war with the evil Dr. Malic, a cruel scientist who wishes to rule mankind all the while conducting genetic experiments on humans and animals. Malic sends his agents to kidnap Dr. Okada, a human scientist who has created a serum that can immunize exposure to radiation.
| Editing | Ume Takeda | Editor |
| Writing | Shinichi Sekizawa | Screenplay |
| Production | Yasuaki Sakamoto | Production Manager |
| Writing | Ted Sherdeman | Screenplay |
| Camera | Taiichi Kankura | Director of Photography |
| Costume & Make-Up | Linda Glazman | Costume Design |
| Directing | Ishirō Honda | Director |
| Production | Eiji Tsuburaya | Production Manager |
| Costume & Make-Up | Kiichi Ishida | Costume Design |
| Art | Maseo Fujiyoshi | Set Decoration |
| Writing | Warren Lewis | Screenplay |
| Sound | Akira Ifukube | Original Music Composer |
| Production | Tomoyuki Tanaka | Executive Producer |
| Production | Don Sharpe | Producer |
| Art | Takeo Kita | Production Design |
